Results 131 to 140 of about 5,439,813 (253)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Female budgerigars prefer males with foraging skills that differ from their own

Animal Cognition
Foraging skills influence food intake and could therefore also play a role in mate choice decision. Previous empirical work has shown that individuals benefit from being in groups that include individuals with a variety of foraging skills as this ...
Yuqi Zou, Zitan Song, Jiani Chen, Yuehua Sun, Michael Griesser   +4 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Collective Household Models: Principles and Main Results. [PDF]

In the traditional approach to consumer behaviour it is assumed that households behave as if they were single decision making units. This approach has methodological, empirical and welfare economic deficiencies.
Frederic VERMEULEN
core  

Breeding‐Related Changes in Social Interactions Among Female Vulturine Guineafowl

Ecology and Evolution
Agonistic and affiliative interactions with group members dictate individual access to resources, and investment in competing for resources is often traded off with other needs. For example, reproductive investment can reduce body condition and, thereby,
Tobit Dehnen, Brendah Nyaguthii, Wismer Cherono, Neeltje J. Boogert, Damien R. Farine   +4 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Running head: Collective Behavior Computational Models of Collective Behavior

, 2008
Computational models of human collective behavior offer promise in providing quantitative and empirically verifiable accounts of how individual decisions lead to the emergence of group-level organizations.
Robert L. Goldstone, Marco A. Janssen
core  

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Perception-driven modeling and synthesis of collective behavior

PERCEPTION-DRIVEN MODELING AND SYNTHESIS OF COLLECTIVE BEHAVIOR Perception-driven modeling and synthesis of collective behavior / Mezey, David (Rights reserved) (-
Mezey, David
core  

Collective Decision Making as the Actualization of Decision Potential [PDF]

This paper presents some characteristics and dilemmas of collective decision making. Collective decision making could be presented as the process of successive crystallization of dominant alternatives under the influence of different decision contexts ...
Andrej Ule
core