Results 131 to 140 of about 578,826 (293)

The Threefold Role of the University in Fostering the Energy Transition: The Case of Bologna and Its Cesena Campus

Energies
As acceleration toward the transition to a carbon-neutral energy production becomes an urgent imperative, universities are called to play a multifaceted role: to produce knowledge and cutting-edge research for the pursuit of energy transition; to ...
Andrea Boeri, Beatrice Turillazzi, Francesca Sabatini, Louise-Nour Sassenou, Gabriele Manella   +4 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Pain and Patient‐Reported Physical Function Did Not Differ Among Body Composition Profiles in Patients With Hip Osteoarthritis

Arthritis Care &Research, EarlyView.
Objective To explore whether higher body fat and lower lean mass are associated with greater pain and worse patient‐reported physical function in individuals with hip osteoarthritis (OA). A secondary aim was to examine whether pain and patient‐reported physical function differ according to four body composition profiles: high body fat, low lean mass ...
Alexandra Ryan, Boliang Wang, Fiona Dobson, Ben Kirk, Travis Haber, Kim L. Bennell, Shirley P. Yu, Kim Allison, Ricardo J. S. Costa, Gabrielle Knox, Michelle Hall   +10 more
wiley   +1 more source

Noise pollution from Arctic expedition cruise vessels: understanding causes, consequences and governance options

npj Ocean Sustainability
Significant increase in shipping in the Arctic has caught international and national attention. The rising presence of touristic expedition cruise vessels might describe a special case for noise as a marine pollutant while they seek exclusive ...
Fabienne Mannherz, Maaike Knol-Kauffman, Vonintsoa Rafaly, Heidi Ahonen, Bjørn Ivar Kruke   +4 more
doaj   +1 more source

Unveiling the social transformative potential of Collective Action in Energy Transition: from energy communities towards a communalism of energy

Historically, significant energy transitions have coincided with turning points in human history, such as shifts from human to animal energy, from animal and biomass to fossil and nuclear energy, and more recently, from fossil to renewable energy due to the climate and ecological crisis.
Dario Padovan, Osman Arrobbio, Alessandro Sciullo, Davide Grasso, Andrea Taffuri, Jacopo Bindi, Francesco Bartolomei, Luca Mastrosimone   +7 more
openaire   +1 more source

Heating reduction as collective action: Impact on attitudes, behavior and energy consumption in a Polish field experiment

Energy and Buildings
Heating and hot water usage account for nearly 80% of household energy consumption in the European Union. In order to reach the EU New Deal goals, new policies to reduce heat energy consumption are indispensable. However, research targeting reductions concentrates either on technical building interventions without considerations of people's behavior ...
Mona Bielig, Łukasz Malewski, Karol Bandurski, Florian Kutzner, Melanie Vogel, Sonja Klingert, Radoslaw Gorzenski, Celina Kacperski   +7 more
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source