Results 141 to 150 of about 6,311,451 (328)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Cellular Energy Cycle Mediates an Advection‐Like Forward Cell Flow to Support Collective Invasion

open access: yesAdvanced Science
Collective cell migration is a model for nonequilibrium biological dynamics, which is important for morphogenesis, pattern formation, and cancer metastasis.
Jian Zhang   +7 more
doaj   +1 more source

p-p minimum-bias dijets and nonjet quadrupole in relation to conjectured collectivity (flows) in high-energy nuclear collisions

open access: yesEPJ Web of Conferences, 2016
Recent observations of ridge-like structure in p-p and p-A angular correlations at the RHIC and LHC have been interpreted to imply collective motion in smaller collision systems.
Trainor Thomas A.
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Evaluation of collective water rights allocation scenarios using the WEAP simulation model in a region of water use conflicts: the case of Formoso River Basin – Tocantins state/Brazil [PDF]

open access: yesRBRH
The aim of the present study was to carry out a hydrological simulation of the Formoso River basin using WEAP and to model scenarios based on the rotating rules of the water pump in regions of conflict for the use of water.
Eduardo Paulino da Silva   +4 more
doaj   +1 more source

Intranuclear cascade models lack dynamic flow [PDF]

open access: yes, 2006
We study the recent claim that the intranuclear cascade model exhibits collective sidewards flow. 4000 intranuclear cascade simulations of the reaction Nb(400 MeV/nucleon)+Nb are performed employing bound and unbound versions of the Cugnon cascade.
Cugnon, Joseph   +4 more
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Multiplicity and event-scale dependent flow and jet fragmentation in pp collisions at s $$ \sqrt{s} $$ = 13 TeV and in p–Pb collisions at s NN $$ \sqrt{s_{\textrm{NN}}} $$ = 5.02 TeV

open access: yesJournal of High Energy Physics
Long- and short-range correlations for pairs of charged particles are studied via two-particle angular correlations in pp collisions at s $$ \sqrt{s} $$ = 13 TeV and p–Pb collisions at s NN $$ \sqrt{s_{\textrm{NN}}} $$ = 5.02 TeV.
The ALICE collaboration   +1054 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

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