Results 51 to 60 of about 2,629,932 (295)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Social networking technology: place and identity in mediated communities [PDF]

open access: yes, 2007
This paper explores the rise of social networking technology as instances of mediated communities. A dialectic between collectivity and place, resulting in the grounding of a shared sense of the past in a particular place, is at the base of all ...
Brown, S.D.   +8 more
core   +1 more source

Developing Researcherhood: Identity Tensions and Identity Work of Women Academics Reflecting on Their Researcher Identity

open access: yesForum: Qualitative Social Research, 2019
In this article, I explore the researcher identity of senior women academics in a South African institution of higher education. The aim was to uncover the identity tensions they experience in relation to being a researcher and to understand how they ...
Helene Antoni Barnard
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Collective nostalgia: a group-level emotion that confers unique benefits on the group [PDF]

open access: yes, 2014
This research established collective nostalgia as a group-level emotion and ascertained the benefits it confers on the group. In Study 1, participants who reflected on a nostalgic event they had experienced together with ingroup members (collective ...
Robertson, S.   +6 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Identity and Islamic Radicalization in Western Europe [PDF]

open access: yes
This paper argues that both socio-economic disadvantage and political factors, such as the West’s foreign policy with regard to the Muslim world, along with historical grievances, play a part in the development of Islamic radicalized collective action in
S Mansoob Murshed, Sara Pavan
core   +2 more sources

Symbolism, Collective Identity, and Community Development

open access: yesSocieties, 2018
A focal point of this article is symbols (e.g., flags) and how low-income communities use them to construct ownership over spaces that would have otherwise been inaccessible to them.
Ivis Garcia
doaj   +1 more source

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