Results 41 to 50 of about 232,783 (214)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Joining collective impact and community science: a framework for core collaborative community science

Ecology and Society
We propose the core collaborative community science framework, an original conceptual framework that integrates and modifies best practices from community science and collective impact groups to support investigations of environmental health and justice.
Monika M Derrien, Weston Brinkley, Dale J Blahna, Alberto J Rodríguez, Roseann Barnhill, Christopher Zuidema, Katie Beaver, Elisabeth Grinspoon, Sarah Jovan   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Shepherding Community Engagement to Strengthen the Local Food System in Northeast Iowa

Journal of Agriculture, Food Systems, and Community Development, 2017
In this case study, we describe how a multistake­holder collaboration in Northeast Iowa is using a type of systems leadership that we call “shep­herding” in order to engage a six-county regional community in creating food systems change.
Arlene E. Enderton, Corry M. Bregendahl, Alice S. Topaloff   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ‘Community of Schools and Services’ (COSS) Model of Early Intervention: A System-Changing Innovation for the Prevention of Youth Homelessness

Youth
Prevention and early intervention have become part of the Australian policy discourse; however, the prevention and early intervention of youth homelessness remain significantly underdeveloped and underfunded in practice.
David MacKenzie, Tammy Hand, Peter Gill
doaj   +1 more source

Rapid City Collective Impact: A City-Wide Effort to Create Quality of Life for All Its Citizens

Interdisciplinary Journal of Partnership Studies, 2016
In Rapid City, South Dakota, community, business, nonprofit, and faith communities leaders, along with a number of citizens across all demographics, are collaborating in a unique plan to create quality of life for all its citizens.
Albert Linderman
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Region-wide collective impact on the Hispanic teacher pipeline [PDF]

School-University Partnerships
PurposeOne of the most persistent issues facing the education profession is the recruitment and retention of high-quality teachers in high-needs schools – in particular, the recruitment and retention of teachers of color.
Erika Mein, Clifton Tanabe
doaj   +1 more source