Results 91 to 100 of about 1,055,262 (297)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Global Dialogue Report - New Emerging Markets: Accra [PDF]

, 2011
The consultation analysed the trends, opportunities and challenges for the future of philanthropy in Africa. The consultation stressed from the outset that Africans should not feel constrained by existing (northern) definitions of philanthropy, but ...

core  

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Laudate Deum: A Framework for Environmental Stewardship and Social Justice in The Philippines and Southeast Asia

CSID Journal of Infrastructure Development
This study explores the intersection of environmental initiatives and social justice movements in the Philippines, a nation rich in biodiversity but acutely vulnerable to climate change and ecological degradation.
Antonio Levy S. Ingles Jr
doaj   +1 more source

COVID-19 Vaccine Acceptance Among Latino/a Immigrants: The Role of Collective Responsibility and Confidence. [PDF]

J Immigr Minor Health, 2023
Kirchoff C, Penn A, Wang W, Babino R, De La Rosa M, Cano MA, Sanchez M.   +6 more
europepmc   +1 more source

Negotiating power relations, gender equality, and collective agency: are village health committees transformative social spaces in northern India? [PDF]

, 2017
BACKGROUND: Participatory health initiatives ideally support progressive social change and stronger collective agency for marginalized groups.
A Dasgupta, A Shukla, A Welbourn, Asha S. George, B Adhikari, C Collins, CM Singh, D Mosse, G Forgia La, Gupteswar Patel, H Lefebvre, HFG Taukobong, J Attride-Stirling, J Butler, JDL Zakus, JM Paxman, Kabir Sheikh, Kerry Scott, M Foucault, M Foucault, M Iwami, M Nichter, NJ Diop, R Loewenson, R Meinzen-Dick, R Nagar, S Molyneux, S Moscovici, S Sohani, SB Rifkin, SB Rifkin, SB Rifkin, Shinjini Mondal, SR Arnstein, Steven A. Harvey, T Abramsky   +35 more
core   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source