Results 31 to 40 of about 1,055,262 (297)
Frontiers in Public Health, 2022 BackgroundDuring the pandemic, a third dose of the COVID-19 vaccine effectively reduces the proportion of severe cases in those infected, but vaccine hesitancy impedes this reasonable prevention method.
Wanqin Gao, Yulin Zhang, Gang Yin
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Diffusion of punishment in collective norm violations
Scientific Reports, 2022 People assign less punishment to individuals who inflict harm collectively, compared to those who do so alone. We show that this arises from judgments of diminished individual causal responsibility in the collective cases.
Anita Keshmirian +4 more
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From Individual to Collective Responsibility: There and Back Again [PDF]
, 2020 This chapter argues that in cases in which a (non-institutional) group is collectively causally responsible and collectively morally responsible for some harm which is either (i) brought about intentionally or (ii) foreseen as the side effect of ...
Ludwig, Kirk
core
Collective punishment depends on collective responsibility and political organization of the target group [PDF]
, 2015 What factors determine the willingness to inflict collective punishment upon a group for a misdeed committed by individual group members? This research investigates the effect of collective responsibility shared among group members and the moderating ...
Berent, J. +4 more
core +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
KAGAWA TOYOHIKO (1888–1960): WITNESS TO THE COSMIC DRAMA
Zygon, 2016 At home and abroad, Kagawa Toyohiko was probably the best‐known Japanese Christian evangelist, social reformer, writer, and public intellectual of the twentieth century, nominated for the Nobel Prize in Literature twice (1947, 1948) and the Nobel Peace ...
doaj +2 more sources
Collective responsibility and the scope of justice
Ethics & Global Politics, 2016 The paper examines Thomas Nagel's ‘political conception’ of justice that holds that the requirements of socioeconomic justice apply only among those persons who are subject to the authority of the same political institutions. The paper has two aims.
Zoltan Miklosi
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source