Results 71 to 80 of about 1,055,262 (297)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Collectives in Cases of Human-Machine Interaction: A Pragmatic Defense of Human-Machine Collectives
Human-Machine Communication JournalHumanity’s future will include greater integration with different kinds of increasingly autonomous and interactive technological systems. Doing so is likely to confront us with reasons to adapt some of our currently accepted concepts and practices.
Niel H. Conradie +3 more
doaj +1 more source
Eksistensi Prinsip Responsibility to Protect Dalam Hukum Internasional
Masalah-Masalah Hukum, 2012 The responsibility to protect (R to P or R2P) is a norm or set of principles based on the idea that sovereignty is not a privilege, but a responsibility. R to P concept focuses on the three pillars. These are : the responsibility of each individual state
Rahayu Rahayu
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Amor Mundi: Why It Is So Difficult to Love the World
PhilosophiesThis paper examines what Hannah Arendt means when she urges us to “love the world as it is” considering that we live in a world that is marred by injustice and violence. The paper is divided into two parts.
Lilian Suzanne Alweiss
doaj +1 more source
ЕТИКА КОЛЕКТИВНОЇ ВІДПОВІДАЛЬНОСТІ В ТЕХНОЛОГІЧНУ ЕПОХУ. (Ethics of collective responsibility in technological epoch.) [PDF]
, 2013 Розглянуто проблему колективної відповідальності за подальший науково-технічний, технологічний, інформаційний розвиток в умовах зростання науково-технічного знання і техніко-техноло-гічної могутності глобалізованої техногенної цивілізації як ...
Терешкун, О. (О. Tereshkun)
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Resistance to teamworking in a UK research and development laboratory [PDF]
, 2015 This article presents an ethnographic exploration of resistance to teamworking in a UK research and development laboratory named RDL. It focuses on the nature of autonomy and responsibility and the implications for resistance. It finds that resistance is
Thursfield, Denise
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Collective responsibility and collective obligations without collective moral agents [PDF]
It is commonplace to attribute obligations to φ or blameworthiness for φ-ing to groups even when no member has an obligation to φ or is individually blameworthy for not φ-ing.
Björnsson, Gunnar
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Nations, Overlapping Generations and Historic Injustice [PDF]
, 2006 This article considers the question of the responsibility that present day generations bear as a result of the actions of their ancestors. Is it morally significant that we share a national identity with those responsible for the perpetration of historic
Butt, Daniel
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