Results 41 to 50 of about 11,427,876 (285)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A new electoral bottom-up model of institutional governance

Scientific Reports
The sustainable governance of Global Risky Commons (GRC)—global commons in the presence of a sizable risk of overall failure—is ubiquitous and requires a global solution. A prominent example is the mitigation of the adverse effects of global warming.
Carlos M. Garrido, Francisco C. Santos, Elias Fernández Domingos, Ana M. Nunes, Jorge M. Pacheco   +4 more
doaj   +1 more source

The New Agile: A Collective Delivery Demand Matrix for Agile, High-Performance, and Dynamic Teams

Administrative Sciences
This article proposes the Collective Delivery Demand Matrix (CDD Matrix), which repositions the New Agile as a correspondence property between collective delivery demands and teams’ operating regimes, aiming to form teams that are simultaneously agile ...
Carlos Alberto Goncalves, Mario S. T. Marques, Felipe Alexandre S. F. Nunes, Daniel Jardin Pardini, Taciana de Barros Jeronimo, Fernando A. M. C. D’Andrea   +5 more
doaj   +1 more source

A Model of Responsive Workplace Law

Osgoode Hall Law Journal, 2012
The North American model of workplace law is broken, characterized by declining frequency of collective bargaining, high levels of non-compliance with employment regulation, and political deadlock.
David J. Doorey
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

IMPLEMENTATION OF FUTURES LITERACY LABS AS A REALIZATION OF THE 17TH POINT OF SDG IN DISASTER RISK REDUCTION

Journal of Social Political Sciences
This research is motivated by the urgency to find new way of looking at Disaster Risk Reduction (DRR) in the TUNA (Turbulent, Uncertain, Novel, Ambiguous) era after the COVID-19 pandemic.
Duta Aksara S. Oesman
doaj   +1 more source

Media and Uncertainty| Understanding the Institutional Precarity of Journalism: A Macro Approach to the Civil Diminishment of Journalism

International Journal of Communication, 2022
This article develops a conceptual framework for understanding risk to journalism, more specifically, risk to the standing of journalism as a civil institution generated by macro-level state and market forces of civil diminishment.
Sara Torsner
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A Modified Risk Theory Model: Theoretical Analysis of Dividends

, 2012
This paper refers to the classical collective risk theory model, mod-ified by the inclusion of a double reflecting barrier. In fact, both the presence of a lower horizontal barrier (i.e.
RAVERA, MARINA
core   +1 more source