Results 31 to 40 of about 30,925 (255)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Healing Echoes: Collective Trauma and Public Narratives in a Divided Homeland

Interlitteraria
This article explores the transformative potential of public storytelling in healing collective trauma, drawing on the case study of the author’s mother, a Cypriot refugee’s experience following the 1974 Turkish invasion.
Andreas Athanasiades
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Alternative Patterns of Literary Progress: Writing about Rwanda in the Wake of Trauma

Metacritic Journal for Comparative Studies and Theory, 2021
This article discusses three books about the 1994 genocide against Rwandan Tutsis, all of which belong to the “Writing as a Duty to Memory” project: two novels by Boubacar Boris Diop and Abdourahman Waberi respectively, and a travel journal by Véronique ...
Maria Chiorean
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Collective Trauma- Psychosocial consequences of war in northern Sri Lanka 10 years on, a mixed methods study

SSM - Mental Health
Introduction: Individuals, families and communities in Sri Lanka, particularly in the North-East of Sri Lanka, have undergone 3 decades of war trauma. Methods: Mixed quantitative and qualitative methods with an integrated, holistic and inclusive approach
Umaharan Thamotharampillai, Ruwanthi Perera, Rajitha Wickremasinghe, Shehan Williams, Thedsanamoorthy Vijayasangar, Balasubramaniam Sivatharsan, Vanceline Hilbert, Daya Somasundaram   +7 more
doaj   +1 more source

Post-traumatic Growth Dimensions Differently Mediate the Relationship Between National Identity and Interpersonal Trust Among Young Adults: A Study on COVID-19 Crisis in Italy

Frontiers in Psychology, 2021
BackgroundIn Italy, the COVID-19 pandemic has caused a collective trauma. Post-traumatic growth (PTG) has been defined as the subjective experience of positive psychological changes as a result of a traumatic event.
Adriano Mauro Ellena, Giovanni Aresi, Elena Marta, Maura Pozzi   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cultural trauma and collective identity [PDF]

Социологический журнал, 2012
The paper deals with the theory of collective trauma, which is built within the framework of the “strong program” in cultural sociology by Jeffrey Alexander.
doaj