Results 241 to 250 of about 398,452 (282)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Development of the PRACTIC Goal Setting Interview (PGSI) for Frail Community-Dwelling Patients. Feasibility, Interrater Reliability and Content validity-a Mixed Methods Study. [PDF]

Patient Prefer Adherence
Væringstad A, Kirkevold Ø, Dalbak ETG, Myhre J, Feiring IH, Bergh S, Lichtwarck B.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Legacy of Conventional Oil and Gas Development Outweighs Shale Gas Impacts on Stream Biodiversity. [PDF]

ACS ES T Water
Olivier-Meehan R, Levi Simons A, Prabhu A, Carter E, Basijokaite R, Lackey G, Wen T.   +6 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Spray drift in arboriculture: A dataset to analyse the influence of spray application techniques, anti-drift nets, and their combinations on the reduction of sedimentary drift, aerial drift and exposure of bystanders. [PDF]

Data Brief
Hudebine Y, Verpont F, Vergès A, Codis S, Perriot B, Pasquier D, Douzals JP, Bedos C, Grimbuhler S, Sellam M, Naud O.   +10 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Policymakers' concerns linking tobacco and Indigenous communities in India: A qualitative analysis of parliamentary questions (1952-2022). [PDF]

PLOS Glob Public Health
Das SS, Bhojani U, Prashanth NS.
europepmc   +1 more source

Undernutrition and Associated Factors Among Adults on Second-Line Antiretroviral Therapy in Debark, Ethiopia: A Cross-Sectional Study. [PDF]

J Int Assoc Provid AIDS Care
Tassew WC, Zeleke AM, Ferede YA, Weldeab AN, Ayenew GM.   +4 more
europepmc   +1 more source

Surface Morphology and Electrochemical Behavior of Microstructured Cu Electrodes in All-Solid-State Sodium Batteries. [PDF]

Molecules
Prior T, Figueira J, Freitas Â, Carvalho D, Gomes BM, Baptista MC, Lebre H, Martins R, Pereira L, Pinto JV, Braga MH.   +10 more
europepmc   +1 more source