Results 221 to 230 of about 154,930 (307)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Quantum information meets high-energy physics: input to the update of the European strategy for particle physics. [PDF]

Eur Phys J Plus
Afik Y, Fabbri F, Low M, Marzola L, Aguilar-Saavedra JA, Altakach MM, Asbah NA, Bai Y, Banks H, Barr AJ, Bernal A, Browder TE, Caban P, Casas JA, Cheng K, Déliot F, Demina R, Di Domenico A, Eckstein M, Fabbrichesi M, Fuks B, Gabrielli E, Gonçalves D, Grabarczyk R, Grossi M, Han T, Hobbs TJ, Horodecki P, Howarth J, Hsu SC, Jiggins S, Jones E, Jung AW, Knue AH, Korn S, Lagouri T, Lamba P, Landi GT, Li H, Li Q, Low I, Maltoni F, McFayden J, McGinnis N, Morales RA, Moreno JM, de Nova JRM, Negro G, Pagani D, Pelliccioli G, Pinamonti M, Pintucci L, Ravina B, Ruzi A, Sakurai K, Simpson E, Sioli M, Su S, Trifinopoulos S, Vahsen SE, Vallecorsa S, Vicini A, Vos M, Vryonidou E, White CD, White MJ, Wildridge AJ, Wu TA, Zani L, Zhang Y, Zoch K.   +70 more
europepmc   +1 more source

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

Advanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel, Nikolas Ebert, Denis Abu Sammour, Sebastian Graf, Björn C. Fröhlich, Emrullah Birgin, Shad A. Mohammed, Nuh N. Rahbari, Axel Wellmann, Oliver Wasenmüller, Cleo‐Aron Weis, Stefan Schmidt, Carsten Hopf   +12 more
wiley   +1 more source

Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses. [PDF]

Crit Care
Landzberg E, Ogdie A, Yarnell C, Harhay MO, Yehya N.   +4 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Toward New Directions in Human Biology: A Roadmap for Anthropological Causal Inference With Observational Data. [PDF]

Am J Hum Biol
Watson EJ, Glass DJ, Petito LC.
europepmc   +1 more source

Photon‐Sphere Modes in Curved Optical Microcavities: A Black‐Hole Analogue Laser

Advanced Science, EarlyView.
An optical analogue of a Schwarzschild black hole is realized using curved microcavities that preserve light‐like geodesics. A new family of laser modes confined around the photon sphere is identified alongside conventional whispering‐gallery modes. Analytical theory, numerical simulations, and experiments reveal curvature‐induced confinement, enabling
Chenni Xu, Aswathy Sundaresan, Nazire‐Begüm Kazkal, Clement Lafargue, Lior Zarfaty, Li‐Gang Wang, Ofek Birnholtz, Dominique Decanini, Melanie Lebental, Patrick Sebbah   +9 more
wiley   +1 more source

Quasi-Power Law Ensembles: Nonextensive Statistics or Superstatistics. [PDF]

Entropy (Basel)
Rybczyński M, Wilk G, Włodarczyk Z.
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source