Results 261 to 270 of about 365,605 (335)

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Pharmacologic Confounders in Steatotic Liver Disease Outcomes Research-Reply. [PDF]

JAMA Intern Med
Ochoa-Allemant P, Hubbard RA, Serper M.
europepmc   +1 more source

Linear collider test facility: ATF2 final focus active stabilisation pertinence

, 2009
Benoît Bolzon, R. Zaidan, A. Seryi, P. Bambade, Yves Rénier   +4 more
openalex   +1 more source

Thermal Shielding and Vapor Transport Enhancement in MOF‐Enabled Membranes for Membrane Distillation

Advanced Science, EarlyView.
A metal–organic framework‐enabled membrane (MEM) with a hierarchical porous structure is developed for thermal‐efficient membrane distillation. By embedding ZIF‐8 onto PH nanofibers, the MEM achieves low thermal conductivity and significantly enhances vapor flux and thermal efficiency.
Xiaolu Li, Shengming Yin, Jianhao Qian, Shahid Ali Khan, Wentao Shang, Jiawei Sun, Muhammad Usman Farid, Gang Lu, Guang Wang, Bhaskar Jyoti Deka, Jiaxin Guo, Yanguang Zhou, Sunwoo Kim, Junghwan Kim, Alicia Kyoungjin An   +14 more
wiley   +1 more source

Investigating the Relationship Between Maternal Smoking During Pregnancy and Offspring Handedness: Extending the Proxy Gene-by-Environment Mendelian Randomization Study Design to Include Polygenic Risk Scores. [PDF]

Behav Genet
Crick DCP, Medland SE, Smith GD, Evans DM.   +3 more
europepmc   +1 more source

Concept of Beam-Related Machine Protection for the Future Circular Collider

, 2019
Yuancun Nie, Ruediger Schmidt, Jan Uythoven, Christoph Wiesner, Daniel Wollmann, Markus Zerlauth   +5 more
openalex   +2 more sources

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Osmolality as a strong predictor of COVID-19 mortality and its possible links to other biomarkers. [PDF]

PLoS One
Cetin S, Ulgen A, Sivgin H, Cetin M, Li W.   +4 more
europepmc   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source