Results 281 to 290 of about 231,980 (350)

Unbiased causal inference with Mendelian randomization and covariate-adjusted GWAS data. [PDF]

HGG Adv
Wang P, Lin Z, Pan W.
europepmc   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

The evolution of selection bias in the recent epidemiologic literature-a selective overview. [PDF]

Am J Epidemiol
Lu H, Howe CJ, Zivich PN, Gonsalves GS, Westreich D.   +4 more
europepmc   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Study of trijet production in proton-proton collisions at different energies. [PDF]

Sci Rep
Mahmoud MA, Gamal M, El-Sharkawy S, Abd Allah NN, Mohamed K.   +4 more
europepmc   +1 more source

Thermal Shielding and Vapor Transport Enhancement in MOF‐Enabled Membranes for Membrane Distillation

Advanced Science, EarlyView.
A metal–organic framework‐enabled membrane (MEM) with a hierarchical porous structure is developed for thermal‐efficient membrane distillation. By embedding ZIF‐8 onto PH nanofibers, the MEM achieves low thermal conductivity and significantly enhances vapor flux and thermal efficiency.
Xiaolu Li, Shengming Yin, Jianhao Qian, Shahid Ali Khan, Wentao Shang, Jiawei Sun, Muhammad Usman Farid, Gang Lu, Guang Wang, Bhaskar Jyoti Deka, Jiaxin Guo, Yanguang Zhou, Sunwoo Kim, Junghwan Kim, Alicia Kyoungjin An   +14 more
wiley   +1 more source

Testing CP-violation in a heavy Higgs sector at CLIC. [PDF]

Eur Phys J C Part Fields
Cheung K, Mao YN, Moretti S, Zhang R.
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials. [PDF]

BMC Med Res Methodol
Shi C, Wei JW, Zhan ZS, Xu XH, Yan ZL, Ou CQ.   +5 more
europepmc   +1 more source

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

Advanced Science, EarlyView.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li, Yaxin Zhu, Yumeng Yan, Jifeng Wang, Lili Niu, Xiang Ding, Mengmeng Zhang, Zhensheng Xie, Tanxi Cai, Xiaojing Guo, Jianming Luo, Peng An, Xiangqian Guo, Fuquan Yang   +13 more
wiley   +1 more source