Results 301 to 310 of about 365,605 (335)

Nanoconfinement‐Steered Molecular Preorganization Enables Efficient Monoethanolamine Degradation through Electronically Modulated High‐Valent Iron–Oxo Pathways

open access: yesAdvanced Science, EarlyView.
Precise modulation of reaction pathways remains an unresolved challenge in peroxymonosulfate‐activated advanced oxidation processes. The spatial preorganization strategy in engineered confinement architecture enables regioselective bond cleavage in monoethanolamine via synergistic proton–electron transfer, redirecting its degradation from nonselective ...
Lin Zhang   +11 more
wiley   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun   +8 more
wiley   +1 more source

Unraveling Energy Flow Mechanisms in Semiconductors by Ultrafast Spectroscopy: Germanium as a Case Study

open access: yesAdvanced Science, EarlyView.
A multi‐technique pump‐probe setup capable of performing both transient reflectivity and time‐resolved Raman spectroscopy after ultrafast excitation, provides a comprehensive understanding of ultrafast electronic and phononic processes. Distinct decay rates for the temperature, frequency, and linewidth of the phonon mode in germanium are observed ...
Grazia Raciti   +10 more
wiley   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu   +10 more
wiley   +1 more source

Pitfalls in performing genome-wide association studies on ratio traits. [PDF]

open access: yesHGG Adv
McCaw ZR   +13 more
europepmc   +1 more source

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