Results 31 to 40 of about 363,681 (249)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The features of the Paleozoic-Mesozoic complexes of Kiber Cape (Chukotka, Arctic Russia): a structural-deforma-tion analysis

Известия высших учебных заведений: Геология и разведка, 2017
Three major regional deformation stages of Central Chukotka tectonic evolution were determined in Paleozoic-Mesozoic deposits of Kiber Cape. The research was based on a structural analysis of the linear and planar elements.
S. M. Katkov
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

A Novel Approach for Modeling Strain Hardening in Plasticity and Its Material Parameter Identification by Bayesian Optimization for Automotive Structural Steels Application

AppliedMath
Constitutive modeling in plasticity is a critical topic in solid mechanics. However, modeling nonlinear plasticity remains a challenge due to the theoretical complexity in representing realistic material behavior.
Teng Long, Leyu Wang, Cing-Dao Kan, James D. Lee   +3 more
doaj   +1 more source

Ship Strike Risk for Fin Whales (Balaenoptera physalus) Off the Garraf coast, Northwest Mediterranean Sea

Frontiers in Marine Science, 2022
Ship strikes are a widespread conservation issue for many cetacean species globally. Population level impacts depend on the occurrence and severity of collisions, which may lead to life altering injuries or fatalities.
Beatriu Tort Castro, Rocío Prieto González, Rocío Prieto González, Seán A. O’Callaghan, Paula Dominguez Rein-Loring, Eduard Degollada Bastos   +5 more
doaj   +1 more source

Data‐Driven Distributed Safe Control Design for Multi‐Agent Systems

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents a data‐driven control barrier function (CBF) technique for ensuring safe control of multi‐agent systems (MASs) with uncertain linear dynamics. A data‐driven quadratic programming (QP) optimization is first developed for CBF‐based safe control of single‐agent systems using a nonlinear controller. This approach is then extended to the
Marjan Khaledi, Bahare Kiumarsi
wiley   +1 more source

Frontal vehicle illumination via rear‐facing lighting reduces potential for collisions with white‐tailed deer

Ecosphere, 2020
Animal–vehicle collisions cause many millions of animal deaths each year worldwide and present a substantial safety risk to people. In the United States and Canada, deer (Odocoileus spp.) are involved in most animal–vehicle collisions associated with ...
Travis L. DeVault, Thomas W. Seamans, Bradley F. Blackwell   +2 more
doaj   +1 more source

Right Atrial Collision Time (RACT): A Novel Marker Of Propensity For Typical Atrial Flutter [PDF]

, 2022
Damian Redfearn, Nick Ryckman, Derek Crinion, Andres Enriques, David Bakker, Sanoj Chacko, Hoshiar Abdollah, Adrián Baranchuk, Christopher S. Simpson   +8 more
openalex   +1 more source