Results 51 to 60 of about 209,510 (304)

Automating the mean-field method for large dynamic gossip networks [PDF]

, 2010
We investigate an abstraction method, called mean- field method, for the performance evaluation of dynamic net- works with pairwise communication between nodes. It allows us to evaluate systems with very large numbers of nodes, that is, systems of a size
Bakhshi, Rena, Endrullis, Jörg, Endrullis, Stefan, Fokkink, Wan, Haverkort, Boudewijn   +4 more
core   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Mechanical Strength and Energy Absorption Optimization of Biomimetic Honeycomb Anti-Collision Pier

Buildings, 2022
The anti-collision pier plays an irreplaceable role in road traffic protection due to its significance. In this research, the biomimetic honeycomb structure was applied to internal anti-collision pier interior structures.
Jianjun Wei, Yufei Wang, Jiaqing Wang, Xupei Yao, Di Wang, Xiangyu Wang   +5 more
doaj   +1 more source

Floquet theory of microwave absorption by an impurity in two dimensional electron gas

, 2017
We investigate the dynamics of a two-dimensional electron gas (2DEG) under circular polarized microwave radiation in presence of dilute localized impurities.
Chepelianskii, A. D., Shepelyansky, D. L.   +1 more
core   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Magmatic record of India-Asia collision [PDF]

, 2015
This work was financially co-supported by Chinese Academy of Sciences (XDB03010301) and other Chinese funding agencies (Project 973: 2011CB403102 and 2015CB452604; NSFC projects: 41225006, 41273044, and 41472061).New geochronological and geochemical data
Cawood, Peter Anthony, Chung, Sun-Lin, Liu, Sheng-Ao, Mo, Xuan-Xue, Niu, Yaoling, Wang, Qing, Wu, Fu-Yuan, Zhao, Zhi-Dan, Zhu, Di-Cheng   +8 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Development of an Anti-collision Model for Vehicles

, 2012
The Anti Collision device is a detection device meant to be incorporated into cars for the purpose of safety. As opposed to the anti collision devices present in the market today, this system is not designed to control the vehicle.
Zungeru, A. M.
core   +1 more source

The fine structure of microwave-induced magneto-oscillations in photoconductivity of the two-dimensional electron system formed on a liquid-helium surface [PDF]

, 2013
The influence of the inelastic nature of electron scattering by surface excitations of liquid helium (ripplons) on the shape of magnetoconductivity oscillations induced by resonance microwave (MW) excitation is theoretically studied.
Dykman M. I., Dykman M. I., Marshall W., Monarkha Yu. P., Ryzhii V. I., Ryzhii V. I., Ryzhii V. I., Ryzhii V. I., Shikin V. B., Shikin V. B., Yu. P. Monarkha   +10 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source