Results 51 to 60 of about 40,505 (291)
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Advanced Science, EarlyView.. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen +8 more
wiley +1 more source
Engineering Transactions, 1983 The present work investigates the optimum choice of collocation points which gives for а given accuracy the minimum number of collocation points. А convergence study has been conducted for the axisymmetric nonlinear analysis of а shallow spherical shell ...
Y. Nath, P.C. Dumir, M.L. Gandhi
doaj
Insights Into the Processing of Collocations During L2 English Reading: Evidence From Eye Movements
Frontiers in Psychology, 2022 We report an eye movement experiment that investigates the effects of collocation strength and contextual predictability on the reading of collocative phrases by L2 English readers.
Hui Li +5 more
doaj +1 more source
Ferroelectric Devices for In‐Memory and In‐Sensor Computing
Advanced Science, EarlyView.Inspired by biological systems, in‐memory and in‐sensor computing overcome von Neumann bottlenecks. Ferroelectric devices can mimic synaptic functions and sense stimuli like light or force, therefore are ideal for these paradigms. This review introduces the ferroelectric devices applied for in‐memory and in‐sensor computing, covering their structures ...
Hong Fang +5 more
wiley +1 more source
On the numerical Picard iterations with collocations for the initial value problem
Journal of Numerical Analysis and Approximation Theory, 2019 Some variants of the numerical Picard iterations method are presented to solve an IVP for an ordinary differential system. The term "numerical" emphasizes that a numerical solution is computed.
Ernest Scheiber
doaj +4 more sources
The stochastic collocation Monte Carlo sampler: highly efficient sampling from ‘expensive’ distributions [PDF]
, 2018 In this article, we propose an efficient approach for inverting computationally expensive cumulative distribution functions. A collocation method, called the Stochastic Collocation Monte Carlo sampler (SCMC sampler), within a polynomial chaos expansion ...
Witteveen, Jeroen +3 more
core +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
MATHICSE Technical Report : Multi-index stochastic collocation for random PDEs [PDF]
In this work we introduce the Multi-Index Stochastic Collocation method (MISC) for computing statistics of the solution of a PDE with random data. MISC is a combination technique based on mixed differences of spatial approximations and quadratures over ...
Nobile, Fabio +3 more
core +2 more sources
Advanced Science, EarlyView.Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais +32 more
wiley +1 more source