Results 181 to 190 of about 5,429 (239)
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu +8 more
wiley +1 more source
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source
This study reports a novel rationally‐designed optical nanoprobe based on dumbbell‐shaped mesoporous silica‐coated gold nanorods, loaded with rare‐earth oxides, photosensitizers, and tumor‐targeted peptides, enabling plasmonic‐enhanced multimodal imaging and PTT‐PDT synergy.
Baikang Zhuang +12 more
wiley +1 more source
In this review, we summarize the recent developments of metal–polyphenol networks (MPNs) as a highly versatile and functionally integrated supramolecular assembly platform. We also discuss their pivotal role in steering biomedical materials away from conventional single‐function designs and toward intelligent, unified diagnostic and therapeutic ...
Kang Zhu +5 more
wiley +1 more source
AZEVs derived from Alpinia zerumbet leaves protect HaCaT keratinocytes from UVB‐induced photoaging by reducing reactive oxygen species (ROS) accumulation, restoring mitochondrial membrane potential, and enhancing ATP production. AZEVs upregulate mitochondrial biogenesis–related proteins, including p‐AMPK/AMPK, SIRT1, PGC‐1α, and Nrf2, thereby improving
Mo‐Rong Xu +3 more
wiley +1 more source
Apple pomace pectin is explored as a sustainable and multifunctional biomaterial for gastric ulcer management. Its unique structural features confer mucoadhesive, anti‐inflammatory, antioxidant, and anti‐Helicobacter pylori activities while enabling nano/microencapsulation of therapeutic agents.
Akash Dhiman +6 more
wiley +1 more source
Excessive alcohol consumption can induce alcoholic liver disease (ALD), and its pathogenesis is closely associated with exacerbated hepatic oxidative stress and inflammatory responses. AST‐FAV are capable of effectively delivering AST to liver tissues, scavenging excessive reactive oxygen species, and blocking the activation of the NF‐κB signaling ...
Chenchen Li +4 more
wiley +1 more source
Investigation Into the Collection and Isolation Workflows of Extracellular Vesicles From Tears
Sampling and isolation methodology shapes tear extracellular vesicle (tEV) composition, influencing housekeeping gene stability, tetraspanin expression, and cytokine levels. Contact lenses and Schirmer Strips provide complementary molecular signatures, while ExoQuick and ultracentrifugation differ in vesicle yield and surface properties.
Nikolay Boychev +4 more
wiley +1 more source
ABSTRACT Plant‐derived extracellular vesicles (EVs) have shown numerous health benefits, including modulation of the human gut microbiota. Herein, we employed isothermal microcalorimetry (IMC) to explore the effects of ginger‐derived nanovesicles (G‐NVs) on the growth and metabolic activity of Bacteroides thetaiotaomicron (Bt), a dominant saccharolytic
Francesca Loria +12 more
wiley +1 more source

