Results 111 to 120 of about 10,020 (239)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág   +5 more
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

open access: yesJournal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá   +4 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

open access: yesResponsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan   +8 more
wiley   +1 more source

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

open access: yesSmall, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira   +9 more
wiley   +1 more source

Osmotic Remodeling of Extracellular Vesicles for Precision Nanomedicine

open access: yesSmall, EarlyView.
Hypotonic lysis in bidistilled water is used to remodel B lymphocyte–derived extracellular vesicles into cargo‐depleted, structurally preserved nanovesicles. The process reduces intraluminal proteins and nucleic acids, reshapes membrane composition, and enhances tumor‐cell uptake in vitro, while allowing proof‐of‐concept reloading with exogenous agents,
Francesca Susa   +18 more
wiley   +1 more source

Factors influencing outcome in patients with colloid cysts who present with acute neurological deterioration. [PDF]

open access: yesJ Clin Neurosci, 2018
Singh H   +7 more
europepmc   +1 more source

A Droplet‐Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients’ Blood Plasma Samples

open access: yesSmall, EarlyView.
This study presents a droplet‐microarray platform integrated with a DNase I‐assisted MoS2 FRET aptasensor for multiplexed profiling of breast cancer subtypes’ exosomes from patients’ plasma. By targeting HER2, MUC1, and CD44, the system enables sensitive detection and accurate discrimination of luminal A, HER2‐positive, and triple‐negative subtypes ...
Yi Liu   +9 more
wiley   +1 more source

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