Results 81 to 90 of about 346,835 (267)

Simple and complicated rectal diverticula: endoscopic analysis of a case series from Brazil

Journal of Coloproctology, 2012
INTRODUCTION: Diverticular disease of the colon is a very common condition, present in most of the elderly population. However, the occurrence of rectal diverticula is extremely unusual. It is typically an incidental finding at colonoscopy.
Guilherme Lang Motta, Kalil Fontana, Carla Bortolin Fonseca, Marcelo Binato, Renato Borges Fagundes   +4 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

Animal Research and One Health
Adoption of microbial preparations is becoming more and more prevalent in the pig breeding industry. Digestive tract microbes are recognized as crucial elements affecting physical characteristics of pigs.
Xiaoyu Huang, Huihui Li, Feng Cheng, Ligang Wang, Guoqing Cao, Lixian Wang, Lijun Shi   +6 more
doaj   +1 more source

Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production

Journal of Advanced Research
Introduction: Colonic fibrosis is a long-term complication of inflammatory bowel disease (IBD), often leading to functional impairment, intestinal obstruction, and surgery.
Haitao Xiao, Tianhang Xing, Miao Qiu, Guangtao Zhang, Gongli Yang, Wenke Chen, Die Hu, Deao Xue, Jiao Peng, Bin Du   +9 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Colonic dilation is associated with increased central line associated blood stream infection for patients with intestinal failure

Intestinal Failure
Introduction: Management of intestinal failure involves supplemental nutrition and complication minimization to achieve enteral autonomy. Previous research to identify prognostic factors in IF focused on the small bowel, yet little work has been done to ...
Pamela Emengo, Shweta S. Namjoshi, James C.Y. Dunn   +2 more
doaj   +1 more source

Acute Pancreatitis Causing Descending Colonic Stricture: A Rare Sequelae

Journal of Investigative Medicine High Impact Case Reports, 2019
An isolated descending colonic stricture is an unlikely complication of acute pancreatitis, with the nonspecific symptoms of colonic stricture making the overall diagnosis difficult.
Amrendra Kumar Mandal MD, Paritosh Kafle MD, Pradip Puri MD, Baikuntha Chaulagai MD, Muhammad Hassan MD, Bikash Bhattarai MD, Rajan Kanth MD, Vijay Gayam MD   +7 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source