Effects of psychological stress on inflammatory bowel disease via affecting the microbiota-gut-brain axis. [PDF]
Chen Y+8 more
europepmc +1 more source
NF2 is Essential for Human Endoderm Development
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong+5 more
wiley +1 more source
Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism. [PDF]
Wang L+12 more
europepmc +1 more source
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao+11 more
wiley +1 more source
pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment. [PDF]
Gvozdeva Y, Staynova R.
europepmc +1 more source
Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen+16 more
wiley +1 more source
The emerging role of intestinal stem cells in ulcerative colitis. [PDF]
Chen S, Qin Z, Zhou S, Xu Y, Zhu Y.
europepmc +1 more source
Influence of diet and disease on human intestinal microflora, colonic function and faecal energy
The availability of energy from the diet is determined by the extent of digestion and absorption and the metabolic activity of the colonic microflora. Attempts to measure the energy available to the body through digestion and absorption presume that all of faecal material is derived solely from dietary residue.
openaire +1 more source
SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi+11 more
wiley +1 more source
Microbial effects of cold-pressed Sacha inchi oil supplementation in rats. [PDF]
Samrit T+7 more
europepmc +1 more source