Results 241 to 250 of about 90,261 (311)

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis. [PDF]

Int J Biol Sci
Yang L, Sun Q, Jiang Z, Yao B, Yang C, Liu G, Yuan L.   +6 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Imaging findings of irritable bowel syndrome patients, and the diagnostic value of irritable bowel syndrome: A systematic review. [PDF]

World J Methodol
Mirghani HO.
europepmc   +1 more source

<i>Eucommia</i> polysaccharides alleviate experimental colitis by reshaping colonic microbiota composition, metabolites, and modulating the IL-17 signaling pathway. [PDF]

Front Microbiol
Yao W, Yan S, Du R, Zhao Y, Zhang H, Wang B, Cheng X, Ma Z, Bao S, Li X, Song Y.   +10 more
europepmc   +1 more source

Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice. [PDF]

Mol Neurobiol
Mekadim C, Mrázek J, Vodička M, Ergang P, Fliegerová KO, Mahayri TM, Chawengsaksophak K, Pácha J.   +7 more
europepmc   +1 more source

Dietary indoles influence the AHR-RORγt axis and mucosal immune homeostasis in ART-treated SIV infection. [PDF]

JCI Insight
Thirugnanam S, Van Zandt AR, McNally AB, Hart VA, Berthelot I, Midkiff CC, Doyle-Meyers LA, Welsh DA, Blair RV, MacLean AG, Rout N.   +10 more
europepmc   +1 more source

Macrophage Immune-Competent Colon Assembloids for Functional Interrogation of Neuroinflammation-Induced Colonic Dysmotility. [PDF]

Gastro Hep Adv
Collier CA, Ortega Sandoval KI, Salikhova A, Rengarajan S, Tharakesh A, Millan AA, Srinivasan S, Raghavan SA.   +7 more
europepmc   +1 more source

Gut microbiotas attributed to disorders and diseases of the gastrointestinal tract, colorectal cancer, bladder cancer: Geographical factors, inflammation, metabolic toxic. [PDF]

World J Gastrointest Pharmacol Ther
Wishahi M.
europepmc   +1 more source