Results 71 to 80 of about 90,261 (311)

Di-n-pentyl phthalate exposure alters intestinal structure and gut microbiota composition and characteristics in mice

Ecotoxicology and Environmental Safety
Background: Di-n-pentyl phthalate (DnPP), a ubiquitous plasticizer structurally analogous to the gut toxicant di-(2-ethylhexyl) phthalate (DEHP), poses environmental persistence and human exposure risks, yet its gastrointestinal toxicity remains poorly ...
Yanyouhong Liu, Liting Zhong, Chaoming Zhou, Yuqin Zhang, Kaiyan Zhang, Yu Gan, Jian Wang, Shuimiao Lin, Gan Xie, Wenyan Zhong, Xiandong Ye, Dongli Linghu, Qi Chen, Weiwei Peng, Chuanhui Cao, Zelei Li   +15 more
doaj   +1 more source

Fecal Microbiota Transplantation Controls Murine Chronic Intestinal Inflammation by Modulating Immune Cell Functions and Gut Microbiota Composition

Cells, 2019
Different gastrointestinal disorders, including inflammatory bowel diseases (IBD), have been linked to alterations of the gut microbiota composition, namely dysbiosis.
Claudia Burrello, Maria Rita Giuffrè, Angeli Dominique Macandog, Angelica Diaz-Basabe, Fulvia Milena Cribiù, Gianluca Lopez, Francesca Borgo, Luigi Nezi, Flavio Caprioli, Maurizio Vecchi, Federica Facciotti   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Study on function of aganglionic colon musculature of hirschsprung's disease murine model.

Japanese Journal of Smooth Muscle Research, 1990
This study examined the function in vitro of aganglionic colon musculature in mice with hereditary aganglionosis--a strain of animals used as a model of Hirschsprung's disease. Double sucrose gap recordings from the muscle strips of both normal and aganglionic colon showed bursts of spike potentials with muscle contraction.
OKASORA, Tatsuo, OKAMOTO, Eizo, TOYOSAKA, Akihiro, NOSE, Katsuyoshi, NAKAI, Yoshiyuki, TOMIMOTO, Yoshifumi   +5 more
openaire   +3 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Analysis of volatile marker compounds in body fluid samples from patients with gastrointestinal disease [PDF]

, 2010
Causes of gastrointestinal diseases such as ulcerative colitis (UC) Crohn’s disease (CD) and irritable bowel syndrome (IBS) are not yet completely understood and clinical investigation for diagnosis is invasive, costly and time consuming.
Fowler, Dawn P.
core  

Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study

, 2022
Background & aims: Colonic eosinophilia, an enigmatic finding often referred to as eosinophilic colitis (EoC), is a poorly understood condition. Whether EoC is a distinct disease or a colonic manifestation of eosinophilic gastrointestinal diseases (EGIDs)
Osswald, Garrett A., Besse, John A., Arva, Nicoleta C., Yang, Guang-Yu, Capocelli, Kelley E, Spergel, Jonathan M, Khoury, Paneez, Rothenberg, Marc E., Leung, John, Hirano, Ikuo, Wechsler, Joshua B., Furuta, Glenn T., Davis, Carla M., Rothenberg, Marc E, Gupta, Sandeep K., Furuta, Glenn T, Aceves, Seema S., Falk, Gary W., Spergel, Jonathan M., Aceves, Seema S, Wechsler, Joshua B, Gupta, Sandeep K, Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR), Capocelli, Kelley E., Mukkada, Vincent, Caldwell, Julie M., Mack, Lydia E., Chehade, Mirna, Menard-Katcher, Calies, Falk, Gary W, Wen, Ting, Dellon, Evan S, Mack, Lydia E, Caldwell, Julie M, Gonsalves, Nirmala, Rochman, Mark, Haberman, Yael, Besse, John A, Collins, Margaret H., Putnam, Philip E., Arva, Nicoleta C, Denson, Lee A, Osswald, Garrett A, Denson, Lee A., Shoda, Tetsuo, Klion, Amy, Mukkada, Vincent A, Davis, Carla M, Putnam, Philip E, Dellon, Evan S., Collins, Margaret H   +50 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics

The Journal of Physiology, 2012
Abstract Intestinal barrier dysfunction is a main feature of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Leak flux diarrhoea and a facilitated uptake of noxious antigens are the two consequences resulting from an impaired epithelial barrier.
Nina A, Hering, Michael, Fromm, Jörg-Dieter, Schulzke   +2 more
openaire   +3 more sources

The role of humoral autoimmunity in gastrointestinal neuromuscular diseases

, 2010
PhDDysfunction of the gastrointestinal neuromuscular apparatus (including interstitial cells of Cajal) is presumed to underlie a heterogeneous group of disorders collectively termed gastrointestinal neuromuscular diseases (GINMDs).
Hubball, Andrew William
core