Results 41 to 50 of about 7,862 (177)

Safety and pharmacokinetics of anumigilimab for hidradenitis suppurativa or palmoplantar pustulosis: A phase 1b study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Anumigilimab, a novel anti‐G‐CSF receptor antibody, was investigated in a phase 1b trial involving 39 patients with hidradenitis suppurativa or palmoplantar pustulosis. No serious safety concerns related to anumigilimab were noted, and PK and PD were dose dependent.
Johannes S. Kern, Simon Francis Thomsen, Georgios Kokolakis, Maurizio Podda, Gregor B. E. Jemec, Kurt Gebauer, Claus Zachariae, John Frew, Pablo Fernandez‐Peñas, Falk G. Bechara, Stefan Beissert, Sourabh Malandkar, Karen Scalzo‐Inguanti, Partha Nandy, Selvakumar Sukumar   +14 more
wiley   +1 more source

Endoscopic Visualization of a Jejuno‐Colonic Fistula in a Case of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma

DEN Open, Volume 7, Issue 1, April 2027.
Monomorphic epitheliotropic intestinal T‐cell lymphoma (MEITL) rarely presents with gastrointestinal fistula formation. A rare case of MEITL is identified in an elderly woman with marked weight loss and hypoalbuminemia, in whom a jejunocolic fistula is directly visualized endoscopically.
Kanami Ota, Yuichi Matsuno, Yoshiaki Taniguchi, Noriyuki Imazu, Shinichiro Kawatoko, Yutaro Ihara, Tomohiro Nagasue, Keisuke Kawasaki, Tomohiko Moriyama, Junji Umeno   +9 more
wiley   +1 more source

Giant Colonic Diverticulitis, an Extremely Rare Presentation of a Rare Disease — Clinical Presentation and Literature Review

Journal of Coloproctology, 2022
Introduction Giant colonic diverticulum (GCD) is rare phenomenon, with less than 200 cases described in the literature. One of the complications of GCD is diverticulitis.
Eliahu Y. Bekhor, Ran Orgad, Hila Shmilovitch, Rotem Ayalon, Oleg Kaminsky   +4 more
doaj   +1 more source

Evaluating the Efficacy of Cytokine‐Directed Therapies in the Management of VEXAS Syndrome

ACR Open Rheumatology, Volume 8, Issue 10, October 2026.
Objective To evaluate the efficacy of cytokine‐directed therapies in VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory somatic) syndrome using previously proposed treatment response criteria. Methods All patients with genetically confirmed VEXAS syndrome who received targeted therapies with JAK inhibitors (JAKi), tumor necrosis factor α inhibitors
Daniel Montes, Hannah E. Langenfeld, Andrew C. Hanson, Cynthia S. Crowson, Mrinal M. Patnaik, Ronald S. Go, Kambiz Kalantari, Yael Kusne, Terra Lasho, Abhishek A. Mangaonkar, Horatiu Olteanu, Kaaren K. Reichard, Megan M. Sullivan, David S. Viswanatha, Kenneth J. Warrington, Matthew J. Koster   +15 more
wiley   +1 more source

A Rare Presentation of Recurrent Diverticulitis in a Patient with Ulcerative Colitis

European Journal of Case Reports in Internal Medicine, 2022
Diverticulitis and ulcerative colitis (UC) are two separate colonic pathologies with different underlying mechanisms. Diverticulosis involves herniation of mucosal and submucosal tissue through muscular tissue in response to increased intraluminal ...
Carlos Perez Hernandez, Sherif Elkattawy, Islam Younes, Paul Fanous, Daphne Gonzalez Aponte, Omar Makanay, Arun Naik   +6 more
doaj   +1 more source

Gastrointestinal adverse effects of GLP‐1 receptor agonists and dual GIP/GLP‐1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents

Nutrition in Clinical Practice, Volume 41, Issue 5, Page 1318-1333, October 2026.
Abstract Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 receptor agonists have transformed the management of type 2 diabetes and obesity. Gastrointestinal (GI) adverse events are the most common limitation of these therapies and a leading cause of discontinuation ...
Vikash Singhani, Muhammad Ehsan, Sara Valencia, Ahmed Nadeem, Eisha Moazzam, Winfield Scott Butsch, Samita Garg   +6 more
wiley   +1 more source

One-day versus four-day antibiotic treatment for acute right colonic uncomplicated diverticulitis: A randomized clinical trial

The Turkish Journal of Gastroenterology, 2019
Background/Aims: Currently, right colonic uncomplicated diverticulitis is typically treated with antibiotic therapy. However, the optimal duration of treatment is unknown. The aim of the present study was to compare the treatment failure rates between 1-
Jung Ho Park, Hyoung Chul Park, Bong Hwa Lee   +2 more
doaj   +1 more source

Colon Single Stripe Sign in Chronic NSAID Use During Norovirus Infection: A Two‐Hit Model of Ischemic Colitis

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT The colon single stripe sign (CSSS) is associated with ischemic‐pattern colonic injury. We report a 69‐year‐old woman with norovirus infection, hematochezia, recurrent left‐sided colitis, and chronic NSAID use found to have CSSS on colonoscopy, suggesting a multifactorial “two‐hit” mechanism involving NSAID‐related mucosal vulnerability and ...
Sushrut Ingawale, Rahul Kothari, Pujitha Vallivedu, Shivaji Karki, Gagandeep Singh Talwar, Jack Jacob, David Regelmann, Prabin Sharma   +7 more
wiley   +1 more source

Global Prevalence of Self‐Reported Alarm Features in the General Population and Among Individuals With Disorders of Gut–Brain Interaction—Results From the Rome Foundation Global Epidemiology Study

United European Gastroenterology Journal, Volume 14, Issue 7, September 2026.
ABSTRACT Background Data on the global prevalence of alarm features in the general population and among individuals with disorders of gut–brain interaction (DGBI) are limited. Methods We analysed data from the Rome Foundation Global Epidemiology Study to estimate the prevalence of fourteen self‐reported alarm features in the global population and among
Jessica Sjölund, Jóhann P. Hreinsson, Brian E. Lacy, Hans Törnblom, Shrikant I. Bangdiwala, Olafur S. Palsson, Ami D. Sperber, Magnus Simren   +7 more
wiley   +1 more source

Does Subspecialization Matter? Institutional Outcomes Before and After Recruitment of Colorectal Surgeons

World Journal of Surgery, Volume 50, Issue 9, Page 2558-2564, September 2026.
Colorectal surgery fellowship is one of the most sought‐after subspecialty programs among general surgery residents, yet most colon and rectal surgeries are performed by general surgeons without specialized training. This study evaluated whether integrating fellowship‐trained colorectal surgeons (CRS) into a general surgery department is associated ...
Amram Kupietzky, Ata Maden, Roi Dover, Eyal Yonathan Juster, Noam Shussman, Bilal Aliyan, Haggi Mazeh, Ido Mizrahi   +7 more
wiley   +1 more source