Results 71 to 80 of about 12,549 (258)

Efficacy and Tolerability of Weekly Bortezomib, Lenalidomide, and Dexamethasone Protocols in Transplant‐Ineligible Newly Diagnosed Myeloma: An Australian Real‐World, Multicenter Study

Asia-Pacific Journal of Clinical Oncology, EarlyView.
RVD with weekly bortezomib dosing in real‐world newly diagnosed transplant‐ineligible myeloma shows comparable efficacy and reduced toxicity compared to twice‐weekly trial protocols. ABSTRACT Background Lenalidomide, bortezomib, and dexamethasone (RVD) remains a standard of care regimen for newly diagnosed multiple myeloma in centers without access to ...
Samantha Kurniawan, Angela Hwang, Nicole Wong Doo, Tracy King, Christian Bryant, Jennifer Zhang, Kristina Whelan, Parisa Fani‐Molky, Giselle Kidson‐Gerber, Annmarie Bosco, Nada Hamad, Gurdeep Parmar, Fiona Kwok, Sam Lai, Silvia Ling, P. Joy Ho, Georgia McCaughan, Adam Bryant   +17 more
wiley   +1 more source

Cost analysis of laparoscopic lavage compared with sigmoid resection for perforated diverticulitis in the Ladies trial [PDF]

, 2017
Background: Laparoscopic peritoneal lavage is an alternative to sigmoid resection in selected patients presenting with purulent peritonitis from perforated diverticulitis.
Bemelman, W.A. (Willem), Lange, J.F. (Johan), Opmeer, B.C. (Brent), Van Dieren, S. (Susan), Vennix, S. (Sandra)   +4 more
core   +5 more sources

Bacterial stimuli activate nitric oxide colonic mucosal production in diverticular disease. Protective effects ofL. casei DG® (Lactobacillus paracaseiCNCM I-1572) [PDF]

, 2017
Background: Micro-inflammation and changes in gut microbiota may play a role in the pathogenesis of diverticular disease (DD). Objective: The objective of this article is to evaluate the expression of nitric oxide (NO)-related mediators and S100B in ...
Andreozzi, Paolo, Cargiolli, Martina, Cuomo, Rosario, De Palma, Giovanni Domenico, Fiore, Walter, Gennarelli, Nicola, Palumbo, Ilaria, Sarnelli, Giovanni, Turco, Fabio, Zito, Francesco Paolo   +9 more
core   +1 more source

Practice Patterns and Outcomes of Preoperative Mechanical Bowel Preparation and Oral Antibiotics for Restorative Elective Colorectal Surgery: Nationwide Analysis of the ACS‐NSQIP Australian Data

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background There is increasing evidence that the addition of preoperative antibiotics (OAB) reduces infectious complications after colorectal surgery. To understand practice patterns in Australia, Australian hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program (ACS‐NSQIP) collecting targeted
Joseph Do Woong Choi, Nguyen Huynh, Kalai Kuppusamy, David Clark, Richard Bryant, Aleksandra Edmundson, Rebecca Radford, Andrew Gilmore, Yasser Farooque, Elaine Zhang, Nimmi Kumar, Matthew Morgan, Neil Merrett, Mingjuan Zeng, Bruce Hodge, Andrew Sutherland, Jimmy Chin Li Lee, Andrea Giles, Diana Tam, Emma Plecas, Boris Strekozov, Chantel Gablonski, Shella de Robles, Jennifer Hearn, Gregory Nolan, Michelle Cooper, Rebecca Boyle, Kelvin Kwok, Ian Incoll, Caitlin Queripel, Amy Cao, Nimalan Pathma‐Nathan, Toufic El‐Khoury, Arthur J. Richardson, Kerry Hitos, James Wei Tatt Toh   +35 more
wiley   +1 more source

Giant Colonic Diverticulitis, an Extremely Rare Presentation of a Rare Disease — Clinical Presentation and Literature Review

Journal of Coloproctology, 2022
Introduction Giant colonic diverticulum (GCD) is rare phenomenon, with less than 200 cases described in the literature. One of the complications of GCD is diverticulitis.
Eliahu Y. Bekhor, Ran Orgad, Hila Shmilovitch, Rotem Ayalon, Oleg Kaminsky   +4 more
doaj   +1 more source

Probiotics in the treatment of diverticular disease. A systematic review [PDF]

, 2016
BACKGROUND AND AIMS: Diverticular disease is a common gastrointestinal condition. Low-grade inflammation and altered intestinal microbiota have been identified as factors contributing to abdominal symptoms.
ANNIBALE, Bruno, Bellisario, Cristina, ESPOSITO, GIANLUCA, Hassan, Cesare, LAHNER, EDITH, Zullo, Angelo   +5 more
core   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Acute Systemic Complications Following High‐Dose Semaglutide Reinitiation in an Elderly Patient

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Severe gastrointestinal intolerance with systemic complications can occur within hours of reinitiating high‐dose semaglutide after a prolonged treatment interruption, even in patients who previously tolerated the medication. Elderly patients with comorbidities may be particularly vulnerable.
Jay Mehta, Brent Tai, Johnathan Frunzi
wiley   +1 more source

Endometriosis: A Rare Cause of Large Bowel Obstruction. [PDF]

, 2018
Large bowel obstruction can result in significant morbidity and mortality, especially in cases of acute complete obstruction. There are many possible causes, the most common in adults being colorectal cancer.
Alexandrino, G, Carvalho, R, Horta, D, Lourenço, L, Reis, J, Sobrinho, C   +5 more
core   +1 more source