Results 161 to 170 of about 79,045 (322)

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source

Ventilator-associated lower respiratory tract infections and bacteremia in medical and surgical critical care patients colonized by multidrug-resistant bacteria. [PDF]

BMC Infect Dis
Torres I, Ferrer J, Colomina J, Clari MÁ, Olea B, Giménez E, Albert E, Sánchez-Jordán P, Aguilar G, Carbonell N, Navarro D.   +10 more
europepmc   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Molecular Characterisation of Fungi Populations in the Chronic Wounds of Filarial Lymphedema Patients in Southern Ghana: A Cross-Sectional Study. [PDF]

Health Sci Rep
Ayeke DY, Osei-Poku P, Byamukama D, Amewu EKA, Abakah A, Shardow ALK, Yeboah SMA, Antwiwaa C, Wilson MB, Wireko S, Larbi A, Kwarteng A.   +11 more
europepmc   +1 more source

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel. [PDF]

Virulence
Lu Y, Wu D, Hu J, Peng G, Zhong J, Liu Y, Li J, Gao Q, Yu XQ.   +8 more
europepmc   +1 more source

Colonizing with Convicts : The British Debate on the Australian Penal Colonies (1802—1838)

, 2015
Vincent Then
openalex   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

The Brief Case: Postoperative pulmonary infection caused by <i>Bordetella hinzii</i>. [PDF]

J Clin Microbiol
Zhou J, Peng H, Ye L, Zhang B, Zhang Y, Zhang L, Qian Y, Yang S.   +7 more
europepmc   +1 more source

Long-Term Colonization by bla CTX-M-Harboring Escherichia coli in Healthy Japanese People Engaged in Food Handling

Applied and Environmental Microbiology, 2016
Kunihiko Nakane, K. Kawamura, Kensuke Goto, Y. Arakawa   +3 more
semanticscholar   +1 more source