Results 201 to 210 of about 71,581 (290)

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

The Brief Case: Postoperative pulmonary infection caused by <i>Bordetella hinzii</i>. [PDF]

J Clin Microbiol
Zhou J, Peng H, Ye L, Zhang B, Zhang Y, Zhang L, Qian Y, Yang S.   +7 more
europepmc   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Murine Models of Klebsiella pneumoniae Gastrointestinal Infection. [PDF]

Curr Protoc
Valencia-Bacca JD, Islam MM, Haas KM, Zafar MA.   +3 more
europepmc   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

Diet-responsive genetic determinants of intestinal colonization in the yeast <i>Candida albicans</i>. [PDF]

mBio
Shubaita M, Oneissi M, Lindemann-Pérez E, Fadhel Alvarez C, Krachler A-M, Proctor DM, Pérez JC.   +6 more
europepmc   +1 more source

Non‐Tariff Measures and U.S. Agricultural Exports

Applied Economic Perspectives and Policy, EarlyView.
Abstract How much do non‐tariff measures (NTMs) affect U.S. agricultural exports? While countries maintain a large and diverse set of NTMs to safeguard the health of plants, animals, and humans, policymakers and regulatory bodies may neglect the impact these measures have on international trade.
Yunus Emre Karagulle, Charlotte Emlinger, Jason H. Grant   +2 more
wiley   +1 more source

Is it time to assign <i>Lactiplantibacillus plantarum</i> as a keystone species in the <i>Drosophila melanogaster</i> microbiota? [PDF]

Appl Environ Microbiol
Chaston JM.
europepmc   +1 more source

AI Guided Protein Design for Next‐Generation Autogenic Engineered Living Materials

Advanced Intelligent Systems, EarlyView.
Autogenic engineered living materials (ELMs) integrate biology and materials science to create self‐regenerating and self‐healing materials. This perspective highlights emerging strategies in protein engineering and AI‐guided de novo design to expand the capabilities of autogenic ELMs.
Hoda M. Hammad, Anna M. Duraj‐Thatte
wiley   +1 more source