Results 111 to 120 of about 92,822 (275)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Discursive and Processual Socialization of the Mass into Acts of Violence: the Case of Rwandan Genocide [PDF]

open access: yes, 2013
This article analyses discursive and processual socialization of the masses into acts of violence during the Rwandan genocide of 1 994. The discursive aspects of the socialization include discourses of dehumanization, ethnic extremism and the dynamics of
Hussein, Jeylan Wolyie
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Un aspect peu connu de la francophonie canadienne de l’Ouest: le français hexagonal

open access: yesCanadian Journal of Applied Linguistics, 2006
One of the little known aspects of the history of “la francophonie” in Western Canada is its inherent complexity, due largely to the fact that it is based on three distinct sources: first, the Mitchifs, descendants of the early “coureurs des bois ...
Robert A. Papen et Anne-Sophie Marchand
doaj  

Military Reform and German Colonists: Expectations and Reality

open access: yesRUDN Journal of Russian History
The author reveals the history of the military reform in Russia in 1874 and the attitude towards it of German colonists and Mennonites who had resettled here during the era of Catherine II and had the privilege of being exempt from military service ...
Olga V. Erokhina
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Characterising Land Holding Size Distributions in a Forest Reserve [PDF]

open access: yes
This paper intends to characterise the land holding distributions in a Multi-Agent Based Simulation (MABS) model inspired by the Caparo Forest Reserve, in Venezuela.
Johanna Alvarez   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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