Results 61 to 70 of about 92,822 (275)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

RUSSIAN PERIODICALS AT THE TURN OF THE 19TH -20TH CENTURIESON RUSSIAN MIGRANTS’ SOCIOCULTURAL ADAPTATION IN CENTRAL ASIA

open access: yesRUDN Journal of Russian History, 2017
In the Russian historiography, the views of the publicists of the early 20th century of the Russian colonists’ life in Central Asia aren’t duly highlighted.
R A Arslanov, A L Klimashin
doaj   +1 more source

Radicals in the Revolution: The Persecution of Christians During the Revolutionary War [PDF]

open access: yes, 2016
This paper explores the plight of radical Christians in Pennsylvania during the American Revolution. Pennsylvania, up until the American Revolution, was governed by Quakers, and home to people of many denominational backgrounds, including various ...
Keane, Kevan D
core   +1 more source

‘A Very Hell of Horrors’? The Haitian Revolution and the Early Transatlantic Haitian Gothic [PDF]

open access: yes, 2015
This article explores the Gothicisation of the Haitian Revolution in the transatlantic discourse during the late eighteenth and early nineteenth centuries.
Hoermann, Raphael
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

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