Results 291 to 300 of about 1,127,670 (388)

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

Associations Between Candida and <i>Staphylococcus aureus, Pseudomonas aeruginosa</i>, and <i>Acinetobacter</i> Species as Ventilator-Associated Pneumonia Isolates in 84 Cohorts of ICU Patients. [PDF]

Microorganisms
Hurley J.
europepmc   +1 more source

Metastatic colonization potential of primary tumour cells in mice

, 1979
David G. Jackson, Janet E. Price
openalex   +1 more source

Bernardo Philippi, Initiator of German Colonization in Chile [PDF]

, 1971
George F. W. Young
openalex   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

Protection induced in pigs previously infected by the non-virulent strain 1330 of Streptococcus suis serotype 2 is not due to the secretion of the bacteriocin suicin. [PDF]

PLoS One
Hau SJ, Fittipaldi N, Payen S, Grenier D, Nielsen DW, Brockmeier SL, Gottschalk M.   +6 more
europepmc   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Impact of Modulator Therapy on the Chronic Colonization of Lower Respiratory Tract Pathogens in Children: Data From Cystic Fibrosis Registry of Turkey. [PDF]

Pediatr Pulmonol
Sunman B, Yalçın E, Erdal MA, Şen V, Başkan AK, Kılınç AA, Yazan H, Çakır E, Demir AD, Ünal G, Savaş S, Pekcan S, Korkmaz M, Canıtez Y, Öztürk GK, Gülen F, Arık E, Keskin Ö, Ersoy A, Köse M, Serbes M, Altıntaş DU, Başaran AE, Bingöl A, Hocoğlu Zİ, Aslan AT, Yuluğ DP, Özdemir A, Tabakçı SÖ, Tural DA, Harmancı K, Özsezen B, Çobanoğlu N, Tongal SN, Çaltepe G, Hangül M, Aydın ZGG, Kılıç M, Hızal M, Baş N, Özcan G, Eyüboğlu TŞ, Emiralioğlu N, Cinel G, Özçelik U, Doğru D.   +45 more
europepmc   +1 more source

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

Aggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu   +10 more
wiley   +1 more source

Strain background interacts with chromosome 7 aneuploidy to determine commensal and virulence phenotypes in Candida albicans. [PDF]

PLoS Genet
Mishra A, Solis NV, Dietz SM, Crouch AL, Filler SG, Anderson MZ.   +5 more
europepmc   +1 more source