Results 121 to 130 of about 7,330 (189)

Timing Intervals and Frequency of Adenoma Surveillance Colonoscopies in Central Queensland, Australia

open access: yesANZ Journal of Surgery, EarlyView.
ABSTRACT Introduction The presence of colonic adenomatous polyps is a risk factor for colorectal cancer. Australian Guidelines changed in 2019 so that the surveillance colonoscopy intervals and polyp risk stratification were changed to reflect evidence available.
Yiu Ming Ho   +2 more
wiley   +1 more source

Surveillance After Pelvic Exenteration: A Systematic Review of Oncological and Functional Follow‐Up

open access: yesANZ Journal of Surgery, EarlyView.
ABSTRACT Background Surveillance following cancer surgery with curative intent serves the purpose of permitting early detection of recurrent disease in addition to monitoring and management of post‐resection functional sequelae. Although recommendations exist for most primary cancers, in the context of radical or re‐operative surgery such as pelvic ...
Adrian Hang Yue Siu   +5 more
wiley   +1 more source

Real‐World Performance of FIT Triage for Symptomatic Colonoscopy: Analysis of the UK National Endoscopy Database (NED)

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
National endoscopy data show that FIT‐based triage clearly outperforms symptom‐based referral for colorectal cancer risk stratification. FIT ≥ 10 identifies high‐risk symptomatic patients, while FIT < 10 confers very low cancer risk, supporting FIT as the primary tool for prioritising colonoscopy in symptomatic pathways.
David Beaton   +4 more
wiley   +1 more source

Downregulation of MLL1 Promotes Intestinal Epithelial Barrier Repair Through Gata4/Bmp4 Activation to Ameliorate Crohn's Disease‐Like Colitis in Mice

open access: yesCell Proliferation, EarlyView.
This study elucidates the pivotal regulatory role and mechanism of MLL1 in inflammatory bowel disease. Experimental data demonstrated elevated MLL1 expression levels in TNBS‐induced murine colitis models, with pharmacological inhibition of MLL1 significantly promoting recovery from CD‐like colitis by accelerating intestinal barrier restoration ...
Xue Song   +12 more
wiley   +1 more source

Comparative effectiveness of combination therapy with SGLT‐2 inhibitors and GLP‐1 RAs compared with SGLT‐2 inhibitors in individuals with type 2 diabetes: A prevalent new‐user cohort study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate the effectiveness of combination therapy with sodium‐glucose cotransporter 2 (SGLT‐2) inhibitors and glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) compared with continued SGLT‐2 inhibitor therapy in routine practice among individuals with type 2 diabetes.
Gregor A. Maier   +3 more
wiley   +1 more source

Human papillomavirus‐associated adenoma of the anorectum

open access: yesHistopathology, EarlyView.
Aims Human papillomavirus (HPV) is the most common sexually transmitted disease in the United States. HPV‐associated invasive anorectal adenocarcinoma has been previously described. In this study, we report the clinicopathological features of three HPV‐associated anorectal adenomas.
Paula Toro   +3 more
wiley   +1 more source

Dysplasia in sessile serrated lesions: frequency, interobserver variability and added value of immunohistochemistry

open access: yesHistopathology, EarlyView.
Sessile serrated lesions with dysplasia represent a critical step in colorectal carcinogenesis. While routine histologic diagnosis is generally reliable and positive diagnostic trends are observed, subtle dysplastic changes may be overlooked. Targeted use of MLH1 immunohistochemistry provides meaningful diagnostic support in selected sessile serrated ...
Valentina Angerilli   +9 more
wiley   +1 more source

Inequities in inflammatory bowel disease care: a Tasmanian case study with proposed solutions

open access: yesInternal Medicine Journal, EarlyView.
Abstract There is well‐recognised inequity of care for people treated with inflammatory bowel disease (IBD) between metropolitan and regional areas. We aim to describe these barriers to care using Tasmania as a case example and to suggest solutions for addressing these barriers that can be used in Tasmania and beyond.
Alexander T Elford   +8 more
wiley   +1 more source

Impact of Diet and Drugs on Fecal Lachnoclostridium Gene Marker (m3) in Non‐Invasive Diagnosis of Colorectal Neoplasia

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background A novel bacterial gene marker, Lachnoclostridium (m3), has potential for non‐invasive diagnosis of colorectal cancer (CRC) and adenoma. Aim This study aims to determine the diagnostic performance of m3 in a multi‐center cohort and to examine the effect of diet and drugs on fecal m3 in subjects with colorectal neoplasia. Methods In a
Min Dai   +10 more
wiley   +1 more source

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