Results 141 to 150 of about 268,406 (174)
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Hemopoietic colony-stimulating factors
Immunology Today, 1984Hemopoietic colony-stimulatingfactors (CSFs) are glycoproteingrowth factors produced by many tissues in the body; they are essential for the survival, growth and differentiation of hemopoietic progenitor cells in vitro. In this article Nicos Nicola and Mathew TTadas discuss the classes of CSF that have now been purified (M-CSF, GM-CSF, G-CSF and Multi ...
N A, Nicola, M, Vadas
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The colony stimulating factors
Medical Oncology and Tumor Pharmacotherapy, 1993Hematopoiesis is a dynamic process, which generate in the range of 10(9) cells/kg each day of erythroid and myeloid cells respectively. In vitro assays that were developed 20 years ago, have been used to define factors that can stimulate growth and differentiation of bone marrow (BM) derived progenitor cells. These growth factors for hematopoiesis were
M, Hansson, T, Söderström
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Granulocyte-Macrophage Colony-stimulating Factor
Biotherapy, 1990Publisher Summary Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of the four classical colony-stimulating factors discovered in the 1960s following the introduction of semi-solid bone-marrow culture techniques. The human GM-CSF gene is located on chromosome 5 (q25–q31) within 10 kb of the interleukin-3 (IL-3) gene and in the same ...
S, Devereux, D C, Linch
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Breast Cancer Research and Treatment, 1989
One of the most exciting recent developments in cancer-related research has been the discovery and understanding of colony-stimulating factors. There is now a general optimism that these factors will be used in the treatment of a variety of solid tumors, lymphomas, and leukemias, as well as in the treatment of patients who are immunocompromised or ...
W L, McGuire +3 more
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One of the most exciting recent developments in cancer-related research has been the discovery and understanding of colony-stimulating factors. There is now a general optimism that these factors will be used in the treatment of a variety of solid tumors, lymphomas, and leukemias, as well as in the treatment of patients who are immunocompromised or ...
W L, McGuire +3 more
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Hematopoietic Colony-Stimulating Factors
1991In summary, hematopoietic growth factors have been discovered, biochemically characterized, cloned, produced by recombinant DNA technology, and put into clinical use in a period of 25 years. We are approaching a greater understanding of the cellular anatomy and molecular mechanisms that regulate production of the CSFs, the ways in which the CSFs ...
K, Kaushansky, C B, Brown, S, Petersdorf
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Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating-Factor)
1990The study of mononuclear phagocytes has been greatly aided by the purification, molecular cloning, and vector-mediated production of biologically active colony-stimulating factors that regulate the proliferation and support the viability of monocytes, macrophages, and their bone marrow progenitors.
C. J. Sherr, E. R. Stanley
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Granulocyte Colony-Stimulating Factor
Southern Medical Journal, 1993Recombinant human granulocyte colony-stimulating factor (G-CSF) is a nonglycosylated protein produced in Escherichia coli using recombinant DNA technology. G-CSF was first defined in vitro as a relatively selective stimulator of pure granulocyte colonies from normal marrow and as a factor that induces differentiation of leukemic cell lines.
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Granulocyte Colony-Stimulating Factors
2004Granulocyte colony-stimulating factor (G-CSF) is a major regulator of the development of antibacterial neutrophilic granulocytic leukocytes (neutrophils). In keeping with the functions of both G-CSF and neutrophils, the murine molecule was first purified from medium that had bathed the dissected lungs of animals previously treated with a bacterial cell-
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British journal of hospital medicine, 1988
The genes for a number of growth factors that stimulate human hematopoietic and lymphoid cells in vitro have recently been cloned and recombinant molecules provided for clinical trials. For three of these (erythropoietin, G-CSF, and GM-CSF), phase I and II studies have been completed and promising results have been obtained.
D F, Williamson, C G, Begley
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The genes for a number of growth factors that stimulate human hematopoietic and lymphoid cells in vitro have recently been cloned and recombinant molecules provided for clinical trials. For three of these (erythropoietin, G-CSF, and GM-CSF), phase I and II studies have been completed and promising results have been obtained.
D F, Williamson, C G, Begley
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Gan to kagaku ryoho. Cancer & chemotherapy, 1987
The nature, type and mechanism of action of various colony stimulating factors (CSFs) have been described. Among these CSFs, injection of the recombinant human granulocyte CSF (rhG-CSF) caused a marked increase in neutrophils in mice as well as in monkeys.
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The nature, type and mechanism of action of various colony stimulating factors (CSFs) have been described. Among these CSFs, injection of the recombinant human granulocyte CSF (rhG-CSF) caused a marked increase in neutrophils in mice as well as in monkeys.
openaire +4 more sources