Results 91 to 100 of about 955,062 (292)
Asia and Africa during Decolonization
Сравнительная политика, 2015 The section assesses the processes of decolonization and the emergence of independent states in the second half of the XX century. A detailed analysis of the roots of decolonization and the nature of this process makes it possible to draw some ...
Viacheslav Iakovlevich Belokrenitskii +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Inducing decision trees with an ant colony optimization algorithm [PDF]
, 2012 Decision trees have been widely used in data mining and machine learning as a comprehensible knowledge representation. While ant colony optimization (ACO) algorithms have been successfully applied to extract classification rules, decision tree induction ...
Otero, Fernando E.B. +2 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Handling continuous attributes in ant colony classification algorithms [PDF]
, 2009 Most real-world classification problems involve continuous (real-valued) attributes, as well as, nominal (discrete) attributes. The majority of Ant Colony Optimisation (ACO) classification algorithms have the limitation of only being able to cope with ...
Otero, Fernando E.B. +5 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
InsectsAnopheles darlingi mosquitoes are the main malaria vectors in the Amazon region and play a significant role in the high transmission cycle of Plasmodium vivax, particularly in areas undergoing degradation of the Amazon. Establishing an An.
José Daniel Costa Pontual +7 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source