Results 121 to 130 of about 160,344 (260)

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

An Ion‐Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR‐Mediated Antibacterial Activity of PEEK

Advanced Materials, EarlyView.
A multifunctional bioactive PEEK‐based implant (Mn@p/MBG‐SPEEK) is engineered to combat implant‐associated infections while promoting osteogenesis. The hybrid surface activates PI3K/Akt/mTOR and AP‐1 signaling pathways for osteogenic differentiation, while Mn coordination induces electronic coupling that narrows the HOMO‐LUMO energy gap and enhances ...
Zhiyan Xu, Ondřej Adam, Marek Doubrava, Ana M. Beltrán, Ivo Dlouhý, Xin Liu, Baiyan Sui, Aldo R. Boccaccini   +7 more
wiley   +1 more source

The colony count of Escherichia coli in the stool of palmar arsenical keratosis following probiotics supplementation

Bangladesh Journal of Pharmacology, 2014
The role of probiotics supplementation for 12 weeks on the colony count of Escherichia coli in the stool of moderate palmar arsenical keratosis (14), arsenic exposed controls (15) and healthy volunteers (9) were studied. The mean colony counts of E. coli
Nafisa Rashid, Mir Misbahuddin, Zubaida Khatoon Choudhry, Ahmed Abu Saleh, Abu Naser Ibne Sattar   +4 more
doaj  

Giant Anisotropy and High Second‐Order Nonlinearity of 3R‐MoS2 for Multifunctional Photonics

Advanced Materials, EarlyView.
Graphical abstract highlights, 3R‐polytype of MoS2 (3R‐MoS2) as a multifunctional photonic platform enabled by giant optical anisotropy and optical nonlinearities, demonstrating subdiffractional waveguiding, giant second‐harmonic (SH) generation, and high‐performance reflective polarization control.
Georgy Ermolaev, Dmitriy Grudinin, Liudmila Klimova, Adilet Toksumakov, Mikhail Gubin, Anton Minnekhanov, Aleksandr Slavich, Mikhail Mironov, Arslan Mazitov, Dmitry Yakubovsky, Nikolay Pak, Andrey Vyshnevyy, Ivan Kruglov, Gleb Tselikov, Alexei Prokhorov, Aleksey Arsenin, Kostya S. Novoselov, Valentyn Volkov   +17 more
wiley   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

Comparative Evaluation of Efficacy of Green Tea Mouth Rinse and Green Tea Gel on the Salivary Streptococcus mutans and Lactobacillus Colony Count in 12-18-year-old Teenagers: A Randomized Clinical Trial. [PDF]

Contemp Clin Dent, 2019
Ahmadi MH, Sarrami L, Yegdaneh A, Homayoni A, Bakhtiyari Z, Danaeifar N, Akhlaghi N.   +6 more
europepmc   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

Solid Particle‐Liquid Metal Mixtures for Robust High‐Current Interconnects in Stretchable Electronics and Soft Robotics

Advanced Materials Technologies, EarlyView.
Metallic microparticles dispersed in liquid metal interconnects mitigate electromigration‐induced failure by reconfiguring internal current density distributions. These fillers facilitate the growth of a robust, protective gallium oxide shell at elevated temperatures, shifting the failure threshold toward a thermal limit.
Ethan J. Krings, Calan Brant, Carson Emeigh, Donovan Vincent Jr., Ravi Tutika, Sangjin Ryu, Eric J. Markvicka   +6 more
wiley   +1 more source

Upcycling Compact Discs Into Ultra‐Stable, Flexible, and Stretchable Nanoporous Gold Electrodes for Enhanced Biosensing Performance

Advanced Materials Technologies, EarlyView.
This article highlights the development of robust and high‐performance flexible and stretchable biosensors that maintain long‐term functionality and optimal electrical conductivity under mechanical deformation, utilizing sustainable and cost‐effective manufacturing principles.
Mousa H. Aldosari, Ahyeon Koh
wiley   +1 more source