Results 81 to 90 of about 811,314 (298)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis in chronic Hepatitis B: Unraveling the immune puzzle - a rare case report with review of literature

IDCases
Background: Hepatitis B virus (HBV) infection affects millions worldwide, predominantly targeting the liver, leading to conditions like cirrhosis and hepatocellular cancer.
Suresh Bhagoowani, Uooja Devi, Aqsa Munir, Ummulkiram Hasnain, Javed Iqbal   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]

, 2019
We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua, Eibl, Guido, Hao, Fang, Rozengurt, Enrique, Sinnett-Smith, James, Wang, Jing, Xu, Qinhong, Yu, Shuo   +7 more
core   +2 more sources

Colonialism in the new digital health agenda

BMJ Global Health
The advancement of digital technologies has stimulated immense excitement about the possibilities of transforming healthcare, especially in resource-constrained contexts. For many, this rapid growth presents a ‘digital health revolution’. While this is true, there are also dangers that the proliferation of digital health in the global south reinforces ...
Sharifah Sekalala, Tatenda Chatikobo
openaire   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Types of Smart Devices Used for Beekeeping, their Development and Possible Perspectives. An Overview

Scientific Papers Animal Science and Biotechnologies
Honeybees are the most known managed social insect species with tremendous contributions to humankind. It is also a highly studied species. Despite extensive research, significant gaps remain in understanding its natural behaviour and survival mechanisms,
Tudor N. Ternar, Alexandru I. Giurgiu, Gianluca Albanese, Adriana C. Urcan, Otilia Bobiș, Daniel S. Dezmirean   +5 more
doaj  

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Rare homozygous CNPY3 variant causing autosomal recessive developmental and epileptic encephalopathy 60: A case report

Rare
Introduction: Epilepsy is one of the most common neurological disorders, affecting around 50 million people globally. Developmental and epileptic encephalopathy 60 (DEE60) is an autosomal recessive disorder caused by mutations in the Canopy FGF signaling
Nohela Rehman, Zohra Hasan Ali, Mahrukh Nasir, Salman Kirmani   +3 more
doaj   +1 more source

Corals of the genus Porites are a locally abundant component of the epibiont community on mangrove prop roots at Calabash Caye, Turneffe Atoll, Belize [PDF]

, 2019
Mangroves are generally regarded as inhospitable for corals, but recent reports suggest they provide ecological refuge for some species. We surveyed diverse mangrove habitats on Turneffe Atoll, Belize, documenting 127 colonies of Porites divaricata (Thin
Atta, Calder, Battaglino, Anya, Bengtsson, Zachary, Burmester, Elizabeth, Finnerty, John, Kaufman, Leslie, Kowalski, Michael, Kuhn, Kirsten, Lesneski, Kathryn, Li, Allen, Margolis, Sarah, Rar, Ekaterina, Scavo Lord, Karina, Stewart, Nathan, Talbot, Matthew, Wafapoor, Marzie   +15 more
core