Results 221 to 230 of about 1,171,416 (281)

Phase I/IIa Study of an Intravitreal Optogenetic Therapy (AGN-151597) in Patients with Advanced Retinitis Pigmentosa. [PDF]

Ophthalmol Sci
Bunnell B, López FJ, Yuan D, Robinson MR, Duncan JL, Birch DG.   +5 more
europepmc   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source

Identification of novel mutations in the <i>GRK1</i> gene in an Algerian family with Oguchi disease. [PDF]

Int J Ophthalmol
Molina Martín JC, García GPG, Campos Mollo E, García Navarro MM, Molina Martín LA, Desco Esteban C, Piñero DP.   +6 more
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Cone Opsins and Inherited Retinal Disease. [PDF]

Cells
Tang M, Park PS.
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Adjacency beats static and dynamic color in bar chart comparison. [PDF]

Iperception
Rummens K, Beier S.
europepmc   +1 more source

Consumer Decision-Making and Ophthalmic Conditions: A Novel Area of Marketing Research. [PDF]

Rom J Ophthalmol
Gheorghe CM.
europepmc   +1 more source

Preexisting Fundus Findings in a Large Cohort of Young Cynomolgus Macaques (<i>Macaca fascicularis</i>) Bred for Ocular Research: Comparison to Humans. [PDF]

J Ocul Pharmacol Ther
Nork TM, Sonnentag PJ, Miller PE, Wabers HD, Rasmussen CA, Katz AW, Kim CBY, Ver Hoeve JN, Eaton JS, Bentley E, Christian BJ, O'Neill CA, Crosson CE, Murphy CJ.   +13 more
europepmc   +1 more source

Artificial intelligence anxiety and its association with willingness to receive AI-related training among maternal and child health nurses: a multicenter network analysis. [PDF]

Front Public Health
Huang C, Zeng Q, Zhu J, Wang Y, Huang X.
europepmc   +1 more source