Results 71 to 80 of about 1,116,443 (297)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tropical Animal Science Journal, 2022 This study evaluated the color fastness and crust quality of eco-printed leather using various types of mordant in the natural dye of mangrove extract. This study used 20 sheepskin crusts and mangrove bark extract.
W. Pancapalaga +2 more
doaj +1 more source
EFFECT OF PAPER SURFACE PROPERTIES ON INK COLOR CHANGE, PRINT GLOSS AND LIGHT FASTNESS RESISTANCE
, 2021 Printability is a combination of paper-related factors that contribute to achieving the desired print quality level and relates to the paper's ability to absorb ink. An important property of ink on paper is its setting behavior.
C. Aydemir +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Improving the Light Fastness of the Wool Dyed with Pomegranate Peels
Journal of Natural Fibers, 2022 Natural dyes are highly promising alternatives; however, their use has some drawbacks such as low light fastness, color yield, and repeatability. The objective of this study is to improve the light fastness of natural dyes.
Zehra Gözütok, M. İbrahim Bahtiyari
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Shodh SariPollution associated with synthetic dyes have caused several health hazards both to human and the environment. In order to curb this trend, especially from industrial effluents, a non – toxic, biodegradable and environmentally compatible dye from nature ...
Abuh Leonard Omachoko +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source