Results 51 to 60 of about 3,742 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Wave Function Collapse Coloring: A New Heuristic for Fast Vertex Coloring

open access: yesCoRR, 2021
7 pages, 3 figures, 1 table and 7 ...
Anh Mac, David Perkins
openaire   +2 more sources

EFFECT OF PAPER SURFACE PROPERTIES ON INK COLOR CHANGE, PRINT GLOSS AND LIGHT FASTNESS RESISTANCE

open access: yes, 2021
Printability is a combination of paper-related factors that contribute to achieving the desired print quality level and relates to the paper's ability to absorb ink. An important property of ink on paper is its setting behavior.

core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Fast, Responsive Decentralized Graph Coloring [PDF]

open access: yesIEEE/ACM Transactions on Networking, 2017
We solve, in a fully decentralised way (\ie with no message passing), the classic problem of colouring a graph. We propose a novel algorithm that is automatically responsive to topology changes, and we prove that it converges quickly to a proper colouring in $O(N\log{N})$ time with high probability for generic graphs (and in $O(\log{N})$ time if $Δ=O(1)
Alessandro Checco, Douglas J. Leith
openaire   +4 more sources

Structural Colored Fabrics with Brilliant Colors, Low Angle Dependence, and High Color Fastness Based on the Mie Scattering of Cu2O Spheres

open access: yes, 2021
Compared with conventional textile coloring with dyes and pigments, structural colored fabrics have attracted broad attention due to the advantages of eco-friendliness, brilliant colors, and anti-fading properties.
Yaqun Han (11731992)   +4 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Improving the Light Fastness of the Wool Dyed with Pomegranate Peels

open access: yesJournal of Natural Fibers, 2022
Natural dyes are highly promising alternatives; however, their use has some drawbacks such as low light fastness, color yield, and repeatability. The objective of this study is to improve the light fastness of natural dyes.
Zehra Gözütok, M. İbrahim Bahtiyari
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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