Results 61 to 70 of about 1,128,183 (289)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Dyeing, fastness and antimicrobial properties of woolen yarns dyed with gallnut (Quercus infectoria Oliv.) extract

, 2012
The present study was conducted to investigate the dyeing, fastness, and antimicrobial properties of woolen yarns using gallnut extract as a natural dye. Comparative results of color fastness (fastness to light, wash, and rub) and colorimetric properties
Ahmad, Aijaz, Khan, Mohd Ibrahim, Mohammad, Faqeer, Manzoor, Nikhat, Yusuf, Mohd, Shahid, Mohammad, Khan, Shafat Ahmad   +6 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Munsell soil color charts

, 2009
[30] p.Las Munsell Soil Color Charts constituyen un método para evaluar el tipo de suelo presente en una zona determinada. El libro está diseñado de manera que permite a los usuarios evaluar el color del suelo en terreno de manera rápida y sencilla.

core   +1 more source

A fast algorithm for coloring Meyniel graphs

Journal of Combinatorial Theory, Series B, 1990
We color the nodes of a graph by first applying successive contractions to non-adjacent nodes until we get a clique; then we color the clique and decontract the graph. We show that this algorithm provides a minimum coloring and a maximum clique for any Meyniel graph by using a simple rule for choosing which nodes are to be contracted.
openaire   +2 more sources

Structural Colored Fabrics with Brilliant Colors, Low Angle Dependence, and High Color Fastness Based on the Mie Scattering of Cu₂O Spheres

, 2021
Compared with conventional textile coloring with dyes and pigments, structural colored fabrics have attracted broad attention due to the advantages of eco-friendliness, brilliant colors, and anti-fading properties.
Yaqun Han (11731992), Shufen Zhang (1465690), Yue Wu (1262184), Zhipeng Meng (586250), Suli Wu (3627575)   +4 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

One-Bath One-Step Dyeing of Polyester/Cotton Blend Fabrics Through Lipase Enzyme Surface Modification

Journal of Natural Fibers
In this study, based on lipase enzyme surface modification, low-temperature dyeing of polyester/cotton fabric with reactive dyes was researched to achieve a one-bath one-step dyeing method.
Worku Tegegne, Adane Haile, Temesgen Feleke   +2 more
doaj   +1 more source