Results 201 to 210 of about 1,443,404 (336)

Achieving Functional and Aesthetic Harmony Through a Fully Digital Workflow for Lateral Agenesis Rehabilitation: A 12-Month Follow-Up. [PDF]

open access: yesJ Esthet Restor Dent
Scotti CK   +5 more
europepmc   +1 more source

Harmony between color and fragrance

open access: yesJournal of Japan Association on Odor Environment, 2011
Kumiko MIURA, Miho SAITO
openaire   +2 more sources

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

open access: yesAdvanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo   +7 more
wiley   +1 more source

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

open access: yesAdvanced Science, EarlyView.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng   +8 more
wiley   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang   +16 more
wiley   +1 more source

Esthetic, Periodontal, and Functional Outcomes of Orthodontic Space Closure Versus Prosthetic Replacement for Congenitally Missing Maxillary Lateral Incisors: A Systematic Review. [PDF]

open access: yesCureus
Althubaiti MM   +13 more
europepmc   +1 more source

Ultrathin‐Gold‐Resonators‐Enabled Bolometers with High Linearity, Responsivity, and Repeatability

open access: yesAdvanced Science, EarlyView.
This work demonstrates ultrathin gold nanomechanical resonators operating in HF/VHF bands, unveiling their potential for laser power sensing. By exploiting frequency shifts resulting from laser‐induced thermal tension, these devices can function as sensitive nanoscale bolometers, with outstanding linearity, responsivity, and repeatability. The findings
Jiaqi Wu   +9 more
wiley   +1 more source

A single-cell transcriptomic dataset profiling traumatic brain injury and NeuroD1-based gene therapy in mice. [PDF]

open access: yesSci Data
Chen R   +9 more
europepmc   +1 more source

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