Results 201 to 210 of about 702,520 (307)

Tectonically driven integration of the 4.8 Ma Colorado River USA tracked with detrital sanidine and fish genetics. [PDF]

open access: yesNat Commun
Karlstrom KE   +8 more
europepmc   +1 more source

Effect of time to palliative epilepsy surgery on outcomes

open access: yesEpilepsia, EarlyView.
Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy duration and seizure reduction in palliative procedures.
Robert M. Crutcher   +34 more
wiley   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

open access: yesEpilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta   +26 more
wiley   +1 more source

Menstrual Profiles and Cardiovascular Markers Among a Cohort of Female Adolescent Athletes. [PDF]

open access: yesInt J Sports Med
Blevins KP   +5 more
europepmc   +1 more source

Changes in effectiveness and safety in patients with Lennox–Gastaut syndrome transitioning from the fenfluramine randomized controlled trial to open‐label extension study

open access: yesEpilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis describing the trajectories of fenfluramine effectiveness and safety, along with dose changes over time, in patients with Lennox‐Gastaut syndrome. Abstract In the phase 3 randomized controlled trial (RCT; NCT03355209) of fenfluramine in Lennox–Gastaut syndrome (LGS),
Rima Nabbout   +14 more
wiley   +1 more source

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

open access: yesEpilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis evaluating the efficacy and safety of fenfluramine in patients with Dravet syndrome stratified by age, number of previously attempted antiseizure medications, and SCN1A pathogenic variant status using data pooled from the three pivotal randomized controlled trials ...
Rima Nabbout   +20 more
wiley   +1 more source

A Parametric Computational Framework for Modeling and Seismic Design of Post‐Tensioned Mass Timber Rocking Walls

open access: yesEarthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Post‐tensioned cross‐laminated timber (PT‐CLT) rocking walls offer a compelling seismic system combining self‐centering behavior with energy dissipation. However, progress in their performance assessment and design has been limited by the lack of a comprehensive parametric modeling tool, as exists for steel or reinforced concrete systems. This
Ghasem B. Shargh   +3 more
wiley   +1 more source

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