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Colorectal Cancer [PDF]

open access: yesActa Oncologica, 2003
Colorectal cancer (CRC) is one of the leading causes of mortality and accounts for approximately 200000 deaths per year in Europe and the USA. Chemotherapy and radiotherapy have established roles in the treatment of colorectal cancer and can contribute to cure rate, prolongation of survival, reduction of local rates of recurrence and enhanced quality ...
Nicum, S, Midgley, R, Kerr, D
openaire   +7 more sources

The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review

open access: yesBiomedicines, 2022
The inflammatory process plays a significant role in the development of colon cancer (CRC). Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation but also impact carcinogenesis at all stages of the disease.
Jędrzej Borowczak   +7 more
doaj   +1 more source

Structural Analysis of SMYD3 Lysine Methyltransferase for the Development of Competitive and Specific Enzyme Inhibitors

open access: yesDiseases, 2021
Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that SMYD3
Dillon K. Jarrell   +4 more
doaj   +1 more source

Histopathology of Polyps and Cancer of Colorectum: A ten years study from a tertiary care center

open access: yesJournal of Gandaki Medical College, 2021
Introduction and objectives: Polyps and colorectal cancer have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone and close clinicopathological correlation is required for correct diagnosis and management.
Binita Goyal
doaj   +1 more source

Robotic-assisted Surgery and its Impact on Patient Outcomes: A Narrative Review [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2023
Robotic-assisted surgery is an advanced surgical technique that combines the skill of a surgeon with the precision and capabilities of robotic systems. This approach has revolutionised the field of medicine by providing enhanced visualisation, improved ...
Simran Chauhan   +2 more
doaj   +1 more source

KRAS-associated microRNAs in colorectal cancer

open access: yesOncology Reviews, 2020
Colorectal cancer (CRC) is one of the leading causes of cancerrelated death worldwide. Despite progress in treatment of cancers, CRC with KRAS mutations are resistant towards anti-EGFR treatment.
Hamizah Ibrahim, Ya Chee Lim
doaj   +1 more source

Colorectal Cancer [PDF]

open access: yes, 2021
Psychological issues around colorectal cancer (CRC) can emerge from the point CRC is suspected, through treatment, to living with or beyond cancer. One-third of patients report high levels of anxiety while undergoing investigations for suspected cancer, and emotional difficulties, particularly anxiety and fear of recurrence, can persist for years ...
Miles, Anne, Redeker, Claudia
openaire   +3 more sources

Predicting Colorectal Cancer Recurrence and Patient Survival Using Supervised Machine Learning Approach: A South African Population-Based Study

open access: yesFrontiers in Public Health, 2021
Background: South Africa (SA) has the highest incidence of colorectal cancer (CRC) in Sub-Saharan Africa (SSA). However, there is limited research on CRC recurrence and survival in SA.
Okechinyere J. Achilonu   +10 more
doaj   +1 more source

Prognostic Significance of Preoperative Globulin-to-albumin Ratio in Obstructive Colorectal Cancer Patients Who Underwent Curative Surgery after Stenting

open access: yesJournal of the Anus, Rectum and Colon, 2021
Objectives: It has been increasingly recognized that the progression of cancer is dependent not only on the tumor characteristics but also on the nutritious and inflammatory condition of the host.
Ryuichiro Sato   +11 more
doaj   +1 more source

Developments in Checkpoint Inhibitor Therapy for the Management of Deficient Mismatch Repair (dMMR) Rectal Cancer

open access: yesCurrent Oncology, 2023
Deficient mismatch repair (dMMR)/microsatellite instability-high (MSIH) colorectal cancer is resistant to conventional chemotherapy but responds to immune checkpoint inhibition (ICI).
Alan Su, Rodrigo Pedraza, Hagen Kennecke
doaj   +1 more source

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