Results 201 to 210 of about 284,773 (249)
Advanced Science, EarlyView.A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen +9 more
wiley +1 more source
Advanced Science, EarlyView.STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang +9 more
wiley +1 more source
Advanced Science, EarlyView.Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He +10 more
wiley +1 more source
Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang +11 more
wiley +1 more source
Advanced Science, EarlyView.SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang +18 more
wiley +1 more source
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Journal of Surgical Oncology, 2022
AbstractAlthough surgery is the established standard and mainstay for treatment of colorectal cancer, advances in technology and clinical trials over the past 50 years have dramatically expanded and improved the detection, staging, treatment, and understanding of this disease.
Philip B. Paty, Julio Garcia‐Aguilar
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AbstractAlthough surgery is the established standard and mainstay for treatment of colorectal cancer, advances in technology and clinical trials over the past 50 years have dramatically expanded and improved the detection, staging, treatment, and understanding of this disease.
Philip B. Paty, Julio Garcia‐Aguilar
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Colorectal specialization and survival in colorectal cancer
Colorectal Disease, 2016AbstractAimIt is recognized that higher surgeon volume is associated with improved survival in colorectal cancer. However, there is a paucity of national studies that have evaluated the relationship between surgical specialization and survival.MethodWe used the Surveillance, Epidemiology, and End Results Medicare cancer registry to examine the ...
G M, Hall +5 more
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The Lancet, 2014
More than 1·2 million patients are diagnosed with colorectal cancer every year, and more than 600,000 die from the disease. Incidence strongly varies globally and is closely linked to elements of a so-called western lifestyle. Incidence is higher in men than women and strongly increases with age; median age at diagnosis is about 70 years in developed ...
Harpreet Wasan, Richard Adams
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More than 1·2 million patients are diagnosed with colorectal cancer every year, and more than 600,000 die from the disease. Incidence strongly varies globally and is closely linked to elements of a so-called western lifestyle. Incidence is higher in men than women and strongly increases with age; median age at diagnosis is about 70 years in developed ...
Harpreet Wasan, Richard Adams
openaire +3 more sources
Diet, Colorectal Adenomas, and Colorectal Cancer
New England Journal of Medicine, 2000Because colorectal cancers usually arise from adenomatous polyps, it is believed that preventing the growth of adenomas in the colon and rectum or removing any that appear will prevent colorectal cancer.1 Many have therefore awaited the results of the two important trials published in this issue of the Journal — a study of wheat-bran fiber by Alberts ...
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Diseases of the Colon & Rectum, 1986
Seven cases of colorectal (five of colonic and two of rectal) tuberculosis are presented. Only one of these patients had associated pulmonary tuberculosis. Radiologic signs of colorectal tuberculosis are nontypical, making the preoperative diagnosis difficult.
A, Chaudhary, N M, Gupta
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Seven cases of colorectal (five of colonic and two of rectal) tuberculosis are presented. Only one of these patients had associated pulmonary tuberculosis. Radiologic signs of colorectal tuberculosis are nontypical, making the preoperative diagnosis difficult.
A, Chaudhary, N M, Gupta
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