Results 301 to 310 of about 5,582,484 (376)

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source

Association of Preoperative Frailty in Older Taiwanese Patients with Colorectal Cancer. [PDF]

Risk Manag Healthc Policy
Wang JS, Lai CC, Huang SH, Liao CK, Hung YS, Chou WC.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

A Nanomodulator Enhances Radiotherapy‐Induced In Situ Cancer Vaccine by Promoting Antigen‐Presenting of Tumor‐Associated Macrophage

Advanced Science, EarlyView.
A nanomodulator (Ft‐E64/Hf@Lipo) is developed, combining radiosensitizer hafnium (Hf) and the cysteine protease inhibitor E64, which cooperatively reinvigorated the antigen presentation of TAMs. Ft‐E64/Hf@Lipo sensitized‐RT generated abundant tumor neoantigens, and then E64/antigens, along with the apoptotic tumor cells, trafficked to TAMs via ...
Xiu Zhao, Mengli Li, Jun Li, Yueying Han, Yu Gong, Zhenzhong Zhang, Jinjin Shi, Cheng‐Yun Jin, Junjie Liu, Pilei Si   +9 more
wiley   +1 more source

Characteristics and significance of γδ T cells in colorectal cancer. [PDF]

Oncoimmunology
Karjalainen H, Härkönen J, Sirniö P, Elomaa H, Äijälä VK, Kastinen M, Tapiainen VV, Väyrynen SA, Ahtiainen M, Helminen O, Wirta EV, Rintala J, Meriläinen S, Saarnio J, Rautio T, Seppälä TT, Böhm J, Mecklin JP, Tuomisto A, Mäkinen MJ, Väyrynen JP.   +20 more
europepmc   +1 more source

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine

Advanced Science, EarlyView.
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li, Yuanyi Zhang, Chenchen Li, Guoping Chen, Pir Muhammad, Yonghong Yao, Lifang Gao, Zhigang Liu, Yanli Wang   +8 more
wiley   +1 more source