Results 191 to 200 of about 187,247 (256)

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Biallelic germline MBD4 mutations predispose to colorectal polyposis, hypermutated AML, and schwannomas. [PDF]

Fam Cancer
Cooper J, Stewart BL, Bokovitz L, Carraway H, Mukherjee S, Liska D, Vasu S, Lesmana H, Blachly JS.   +8 more
europepmc   +1 more source

Cardiovascular disease incidence and cancer risk in two large European prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Cardiovascular disease (CVD) and cancer share risk factors and biological mechanisms, raising questions about potential associations between the two, particularly regarding CVD duration and cancer onset. Whether CVD influences subsequent cancer risk, however, remains inconclusive.
Emma Fontvieille, Vivian Viallon, Laia Peruchet‐Noray, Quan Gan, N. Charlotte Onland‐Moret, Yvonne Koop, Anne Tjønneland, Nicola Patricia Bondonno, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Catarina Schiborn, Calogero Saieva, Vittorio Simeon, Claudia Agnoli, Rosario Tumino, Fulvio Ricceri, Leila Luján‐Barroso, Maria‐José Sánchez, Conchi Moreno‐Iribas, Konstantinos K. Tsilidis, Marc J. Gunter, Adam Butterworth, Elio Riboli, Heinz Freisling, Pietro Ferrari   +25 more
wiley   +1 more source

Stage IV Rectal Adenocarcinoma After Negative Multitarget Stool DNA-Fecal Immunochemical Test in a Symptomatic Patient: Misapplication of a Screening Test in a Diagnostic Context. [PDF]

Cureus
Omari Y, Nohomovich B, Sallam D, Sorser S.   +3 more
europepmc   +1 more source

Cutaneous Metastasis From Rectal Adenocarcinoma Mimicking Vegetative Genital Herpes: A Case Report. [PDF]

Cureus
González Uribe A, González Sánchez VL, Blanquet Campos DS, Aceves Villalvazo MA.   +3 more
europepmc   +1 more source

Subsequent primary neoplasm risk among survivors of cancer in adolescence and young adulthood: a population-based study from Alberta, Canada. [PDF]

CMAJ
Ul Alam A, Tchir D, McKillop S, Logie N, Cavanaugh T, Nathan PC, Reynolds KA, Fidler-Benaoudia MM.   +7 more
europepmc   +1 more source

Assessing Concordance of Cancer Registry Data and Electronic Health Record Data in Metastatic Cancer: a Cohort Study of Patients with Colorectal Liver Metastasis in a U.S. Integrated Health System. [PDF]

Cancer Epidemiol
Brauer DG, Sekiya A, Vobugari N, Prakash A, Ozed-Williams B, Ecker BL, Ankeny JS, Jensen EH, Marmor S.   +8 more
europepmc   +1 more source

Combined analysis of metabolomics and transcriptomics reveals new indicators for the diagnosis and prognosis of colorectal cancer. [PDF]

Contemp Oncol (Pozn)
Guo M, Jin B.
europepmc   +1 more source

The Vital Role of Family Physicians in the Screening and Early Detection of Lynch Syndrome: A Case Report. [PDF]

Cureus
Campelos J, Gomes M, Campos A, Cardoso M, Lopes M.   +4 more
europepmc   +1 more source