Results 241 to 250 of about 3,157,739 (436)

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

Indocyanine green and height of anastomosis in colorectal surgery- a network meta-analysis. [PDF]

Langenbecks Arch Surg
Fok KY, Toh JW.
europepmc   +1 more source

Comparison of concentrations of two doses of clavulanic acid (200 and 400 milligrams) administered with amoxicillin (2,000 milligrams) in tissues of patients undergoing colorectal surgery

, 1995
C. Martín, M N Mallet, B. Sastre, X. Viviand, A. Martin, P. De Micco, F. Gouin   +6 more
openalex   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Scaling robotic surgery: the role, responsibilities and challenges of robotic proctorship in colorectal surgery. [PDF]

J Robot Surg
Harji DP, Mohan H, Coates R, Miskovic D, Evans C, Davies RJ, Torkington J, Khan J, Association of Coloproctology of Great Britain and Ireland (ACPGBI) Robotic Clinical Advisory Group.   +8 more
europepmc   +1 more source

Continuous Epidural Morphine for Postoperative Pain Management after Gastric and Colorectal Surgery.

, 1996
Takahiko Fukuchi, Atsuyoshi Onitsuka, Masatomo HAYASHI, Shoshi Senga, Yoshifumi Katagiri, Masatoshi Hayahi, Naoki Imai, Masaya Shibata, Kimi YAMAUCHI, Noaki Futamura, Yasuhiro Sumi, Hajime Hirose   +11 more
openalex   +2 more sources

Lower endoscopy after curative colorectal cancer surgery: It's not just cancer surveillance [PDF]

, 2001
William C. Cirocco
openalex   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
wiley   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Artificial intelligence in colorectal surgery multidisciplinary team approach-From innovation to application. [PDF]

Physiol Rep
Murtada A, Kayali F, Jubouri M, Ghattas SNS, Rezk SSS, Mir FA, Williams I, Bashir M, Bailey DM.   +8 more
europepmc   +1 more source