Results 281 to 290 of about 3,282,422 (392)

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Development of a Clinical Prediction Model for Anastomotic Leakage in Colorectal Surgery.

JAMA Netw Open
Ochs V, Taha-Mehlitz S, Lavanchy JL, Steinemann D, Müller BP, Rosenberg R, Flaifel M, Enodien B, Frey DM, Baltuonis M, Vorburger S, Flemming S, Kollmann L, Lock JF, Staartjes VE, Grass JK, Melling N, Rousek M, Degutyte AE, Abeciunas V, Poskus T, Ponholzer F, Öfner D, El-Hussuna A, Bardakcioglu O, Neumann K, Spence RT, Sutton T, Honaker MD, Cattin PC, Taha A, 2015 European Society of Coloproctology Collaborating Group.   +31 more
europepmc   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Efficacy of Enhanced Recovery after Surgery (ERAS) Protocols in Pediatric Colorectal Surgery: A Randomized Controlled Trial.

J Pharm Bioallied Sci
Tirkey K, Ankita, Xess NG, Sahu SS, Singh AK, Ranjan A, Lakra PS, Birua H.   +7 more
europepmc   +1 more source

Continuous wound infiltration versus placebo following elective minimally invasive colorectal surgery (CIMICS): study protocol for a randomised controlled trial. [PDF]

PLoS One
Glazemakers S, Ketelaers SHJ, Scholten HJ, Schipper RJ, Meesters MI, Burger JWA, Bloemen JG.   +6 more
europepmc   +1 more source

Has high compliance with enhanced recovery after surgery protocol improved 5-year survival? A cohort study of 468 non-metastatic colorectal cancer patients [PDF]

Magdalena Pisarska, Karolina Zawadzka, Grzegorz Torbicz, Urszula Popiela, Piotr Małczak, Michał Wysocki, Piotr Major, Mateusz Rubinkiewicz   +7 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Serum calprotectin as a biomarker for postoperative complications in colorectal surgery: a pilot study defining normal postoperative dynamics. [PDF]

BMC Surg
von Ahnen T, von Ahnen M, Eck M, Schardey J, Schopf S, D Haese J, Kühn F, Schardey HM, Wirth U.   +8 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Immediate Mobilisation After Elective Colorectal Surgery-Patients' and Healthcare Professionals' Experiences: A Qualitative Study. [PDF]

Scand J Caring Sci
Thörn RW, Forsberg A, Ahlstrand R, Anderzén-Carlsson A.   +3 more
europepmc   +1 more source