Results 51 to 60 of about 97,002 (242)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Research on the Impact of Lighting Illuminance and Color on Creative Performance and Mood

Buildings
With the development of the knowledge economy, the significance of the creative industry has become increasingly prominent. Individual creativity can be stimulated by optimal lighting.
Bo Zhou, Yangxiaoxiao Zhou, Qixuan Ren, Li Peng, Yang Guan, Haiyin He   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Influence of Cinema Screen Colors on The Heart Rate and Blood Pressure among Students in the College of Fine Arts

Diyala Journal of Medicine, 2020
Background: The strong relationship between hypertension and stress have been confirmed in previous studies. The stress has been shown in rise blood pressure by rising heart rate and the cardiac output .
Rajaa Hameed Rasheed
doaj   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Influência do método de ativação sobre a resistência flexural de um cimento resinoso de dupla polimeração [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Odontologia.O propósito deste estudo foi avaliar a influência da fotoativação através da porcelana sobre a resistência flexural de ...
Rebelatto, Cassius
core  

3-D shape reconstruction of non-uniform reflectance surface based on pixel intensity, pixel color and camera exposure time adaptive adjustment

Scientific Reports, 2021
High dynamic range 3-D shape measurement is a challenge. In this work, we propose a novel method to solve the 3-D shape reconstruction of high-reflection and colored surfaces. First, we propose a method to establish a fast pixel-level mapping between the
Jianhua Wang, Yanxi Yang, Yuguo Zhou
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A dual-functional curcumin strategy for light scattering mitigation in high-fidelity DLP ceramic 3D printing

International Journal of Extreme Manufacturing
Light scattering remains a critical barrier in digital light processing (DLP)-based ceramic additive manufacturing, particularly for achieving high precision, fine resolution, and complex geometries.
Mingyue Cao, Wenxin Wang, Xingyu Yang, Wei Zhu, Xiaolong Zhu, Yinfeng He, Feng Chen, Xiaoxiao Han   +7 more
doaj   +1 more source