Results 41 to 50 of about 362,643 (306)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The construction of colorimetry by committee [PDF]

, 1996
This paper explores the confrontation of physical and contextual factors involved in the emergence of the subject of color measurement, which stabilized in essentially its present form during the interwar period. The contentions surrounding the specialty
Johnston, S.F.
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Evaluation of urinary hydroxyproline and creatinine level in patients with benign mandibular odontogenic tumor

Clinical and Experimental Dental Research, 2021
Background Odontogenic tumors are relatively common oro‐facial tumors seen in our environment with challenges encountered with management in terms of inadequate infrastructure and high cost of treatment.
Chidozie I. Onwuka, Chibuzo C. Uguru, Chidinma I. Onwuka, Ambrose E. Obiechina   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Detection for hydrogen peroxide in milk by the nanozyme based on Ag/g-C3N4

Shipin yu jixie
ObjectiveTo develop a colorimetric analysis method for the rapid detection of H2O2 in milk.MethodsA novel composite nanozyme material, Ag/g-C3N4, is synthesized by loading nano-Ag on the surface of g-C3N4 nanosheets via a reduction method.
ZHU Yanfeng, WANG Songnan
doaj   +1 more source

Inkjet printed LED based pH chemical sensor for gas sensing [PDF]

, 2009
Predictable behaviour is a critical factor when developing a sensor for potential deployment within a wireless sensor network (WSN). The work presented here details the fabrication and performance of an optical chemical sensor for gaseous acetic acid ...
Abe, Allain, Bae, Beirne, Bharathan, Byrne, Carter, Crowley, Crowley, Crowley, Dermot Diamond, Diamond, Diamond, Gordon G. Wallace, Grady, Hasenbank, Haverinen, Hayes, Hebner, Janata, Janzen, Kim, Lau, Leopold, Li, Mabrook, Magdassi, Martina O’Toole, Nivens, Nivens, O’Toole, O’Toole, Pacquit, Pacquit, Rakow, Rakow, Reis, Roderick Shepherd, Rogers, Shepherd, Shepherd, Shepherd, Spadavecchia, Stewart, Weigl   +44 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Establish intelligent detection system to evaluate the sugar smoking of chicken thighs

Poultry Science, 2021
: The objective of this study was to establish a standardized color detection method to achieve low-cost, rapid, nonintrusive and accurate characterization of the color change of smoked chicken thighs during the smoking process.
Bo Wang, Hongyao Yang, Fenggui Lu, Fangzhu Yu, Xiaodan Wang, Yufeng Zou, Dengyong Liu, Jianbo Zhang, Wenyun Xia   +8 more
doaj   +1 more source

Optimization Of Detergent-Mediated Reconstitution Of Influenza A M2 Protein Into Proteoliposomes [PDF]

, 2018
We report the optimization of detergent-mediated reconstitution of an integral membrane-bound protein, full-length influenza M2 protein, by direct insertion into detergent-saturated liposomes.
Arbuckle, Douglas Stuart, , \u2717, Bost, Margaret H., , \u2717, Crouch, Catherine Hirshfeld, Green, Bryan M., , \u2716, Grossman, Carl H., Howard, Kathleen P., Kim, Tae H., , \u2714   +6 more
core   +2 more sources